A ZIF-90 nanoplatform loaded with an enzyme-responsive organic small-molecule probe for imaging the hypoxia status of tumor cells
文献类型：期刊论文
| 作者 | Zou, Ruifen; Gong, Qiuyu; Shi, Zhenzhi; Zheng, Jianping; Xing, Jie; Liu, Chuang; Jiang, Zhenqi; Wu, Aiguo |
| 刊名 | NANOSCALE
 |
| 出版日期 | 2020 |
| 卷号 | 12期号:27页码:14870-14881 |
| 关键词 | FLUORESCENT-PROBE NITROREDUCTASE RADIOTHERAPY FRAMEWORK-90 OXYGENATION RESISTANCE MEMBRANE FUNCTIONALIZATION NANOPARTICLES NANOCRYSTALS |
| DOI | 10.1039/d0nr02580a |
| 英文摘要 | Hypoxia is one of the most common and important features occurring across a wide variety of malignancies, which can have adverse effects on the therapeutic outcomes of chemotherapy and radiotherapy. Therefore, the characterization of tumor hypoxia is of great importance in clinical tumor treatment. Herein, we firstly develop a new spectroscopic off-on probe with high sensitivity (detection limit: 5.8 ng mL(-1)) and good selectivity for fluorescence imaging the hypoxic status of tumor cellsviaits enzymatic reaction with nitroreductasein vitroandin vivoin the presence of dimethyl sulfoxide (DMSO) as a co-solvent. Inspired by the recent investigations on metal-organic frameworks (MOFs), a dual pH and ATP-responsive ZIF-90 nanoplatform was synthesized, and then PEG was post-modified through a Schiff base reaction. This allows the platform to serve as a carrier to load the hypoxia-responsive probe to investigate its response to enzyme in cells and in mice without using dimethyl sulfoxide as a co-solvent. Consequently, the two probes we synthesized here can successfully respond to nitroreductase for turn-on fluorescence imaging at a cellular level and in tumor-bearing mice. This is the first time that an enzyme-responsive organic small-molecule probe has been mounted on one of the MOFs. Our results open up a promising way for the design and application of both enzyme-responsive probes and MOFs. |
| 学科主题 | Chemistry ; Science & Technology - Other Topics ; Materials Science ; Physics |
| 源URL | [http://ir.nimte.ac.cn/handle/174433/20640]  |
| 专题 | 2020专题 2020专题_期刊论文 |
| 作者单位 | 1.Zheng, JP 2.Wu, AG (corresponding author), Chinese Acad Sci, Ningbo Inst Mat Technol & Engn, Zhejiang Engn Res Ctr Biomed Mat, Ningbo 315201, Peoples R China. 3.Wu, AG (corresponding author), Chinese Acad Sci, Ningbo Inst Mat Technol & Engn, Cixi Inst Biomed Engn, Chinese Acad Sci CAS Key Lab Magnet Mat & Devices, Ningbo 315201, Peoples R China. |
| 推荐引用方式 GB/T 7714 | Zou, Ruifen,Gong, Qiuyu,Shi, Zhenzhi,et al. A ZIF-90 nanoplatform loaded with an enzyme-responsive organic small-molecule probe for imaging the hypoxia status of tumor cells[J]. NANOSCALE,2020,12(27):14870-14881. |
| APA | Zou, Ruifen.,Gong, Qiuyu.,Shi, Zhenzhi.,Zheng, Jianping.,Xing, Jie.,...&Wu, Aiguo.(2020).A ZIF-90 nanoplatform loaded with an enzyme-responsive organic small-molecule probe for imaging the hypoxia status of tumor cells.NANOSCALE,12(27),14870-14881. |
| MLA | Zou, Ruifen,et al."A ZIF-90 nanoplatform loaded with an enzyme-responsive organic small-molecule probe for imaging the hypoxia status of tumor cells".NANOSCALE 12.27(2020):14870-14881. |
入库方式： OAI收割
来源：宁波材料技术与工程研究所
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