Tandem post-synthetic modification of a zeolitic imidazolate framework for CXCR4-overexpressed esophageal squamous cell cancer imaging and therapy
文献类型：期刊论文
| 作者 | Cao, Yi; Jiang, Zhenqi; Li, Yanying; Wang, Yinjie; Yang, Yong; Akakuru, Ozioma Udochukwu; Li, Juan; Wu, Aiguo |
| 刊名 | NANOSCALE
 |
| 出版日期 | 2020 |
| 卷号 | 12期号:24页码:12779-12789 |
| 关键词 | METAL-ORGANIC FRAMEWORKS LYMPH-NODE METASTASIS PREOPERATIVE CHEMORADIOTHERAPY FAVORABLE BIOCOMPATIBILITY CXCR4 EXPRESSION AMPLIFICATION PATTERNS BINDING |
| DOI | 10.1039/d0nr00895h |
| 英文摘要 | Zeolitic imidazolate frameworks (ZIFs) as emerging porous materials have attracted remarkable attention for their unprecedented porosity and acidic sensitive degradation that enables high drug loading and microenvironment responsive fast payload release. However, the limited functions and disadvantages of ZIF5 such as early drug release, potential cytotoxicity inducing damage to major organs, and even death of animals, impede their further biomedical application. In this work, we report the first tandem post-synthetic modification of ZIF-7 with both metal ions and organic ligands. Inspired by the benzimidazole-like inhibitors that are similar to the organic ligand of ZIF-7, a chemokine (C-X-C motif) receptor 4 (CXCR4) inhibitor AMD-070 (AMD) and magnesium ions (Mn2+) were successfully tandem exchanged to the ZIF-7 framework, forming an active-targeting framework AMD-ZIF-7(Mn) for CXCR4-overexpressed esophageal squamous cell cancer. The obtained AMD-ZIF-7(Mn) showed good biocompatibility in vitro and in vivo. Meanwhile, it exhibited an excellent T-1-weighted magnetic resonance imaging performance and CXCR4 targeting ability. With 5-Fu loading, AMD-ZIF-7(Mn)/5-Fu showed a synergistic therapeutic effect in DNA damage and CXCR4 inhibition of esophageal squamous cell cancer. Therefore, we propose a structural reconstruction method to effectively explore and improve the biomedical application of ZIF5 in esophageal squamous cell cancer theranostics. |
| 学科主题 | Chemistry ; Science & Technology - Other Topics ; Materials Science ; Physics |
| 源URL | [http://ir.nimte.ac.cn/handle/174433/20696]  |
| 专题 | 2020专题 2020专题_期刊论文 |
| 作者单位 | 1.Wu, AG (corresponding author), Chinese Acad Sci, CAS Key Lab Magnet Mat & Devices, Zhejiang Engn Res Ctr Biomed Mat, Cixi Inst Biomed Engn,Ningbo Inst Mat Technol & E, Ningbo 315201, Peoples R China. 2.Li, J |
| 推荐引用方式 GB/T 7714 | Cao, Yi,Jiang, Zhenqi,Li, Yanying,et al. Tandem post-synthetic modification of a zeolitic imidazolate framework for CXCR4-overexpressed esophageal squamous cell cancer imaging and therapy[J]. NANOSCALE,2020,12(24):12779-12789. |
| APA | Cao, Yi.,Jiang, Zhenqi.,Li, Yanying.,Wang, Yinjie.,Yang, Yong.,...&Wu, Aiguo.(2020).Tandem post-synthetic modification of a zeolitic imidazolate framework for CXCR4-overexpressed esophageal squamous cell cancer imaging and therapy.NANOSCALE,12(24),12779-12789. |
| MLA | Cao, Yi,et al."Tandem post-synthetic modification of a zeolitic imidazolate framework for CXCR4-overexpressed esophageal squamous cell cancer imaging and therapy".NANOSCALE 12.24(2020):12779-12789. |
入库方式： OAI收割
来源：宁波材料技术与工程研究所
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