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Distinct dietary cadmium toxic effects and defense strategies in two strains of gibel carp (Carassius gibelio) revealed by a comprehensive perspective

文献类型：期刊论文

作者Li, Hongyan1,2; Xu, Wenjie2; Wu, Liyun1,2; Dong, Bo1,2; Jin, Junyan2; Han, Dong2; Zhu, Xiaoming2; Yang, Yunxia2; Liu, Haokun2; Xie, Shouqi2
刊名CHEMOSPHERE
出版日期2020-12-01
卷号261页码:11
ISSN号0045-6535
关键词Dietary cadmium Strain ER stress Autophagy Lipid metabolism
DOI10.1016/j.chemosphere.2020.127597
通讯作者Jin, Junyan(jinjunyan@ihb.ac.cn)
英文摘要Previous studies demonstrated that gibel carp A strain was more susceptible to herpesvirus infection than other strains. Thus, we hypothesized that F strain might display better defense responses than the A strain against cadmium (Cd) exposure. To test our hypothesis, gibel carp A strain and F strain were exposed to three diets comprising of different concentrations of Cd for 8 weeks to compare their resistances to Cd. Comprehensive evaluations on biochemical, physiological and histological responses were conducted post-exposure. Results showed that no adverse effects and differences were observed on growth in two strains of gibel carp, compromising of the remarkable hepatoxicity-caused liver damage as shown by histological observations. Dietary Cd exposure stimulated antioxidant defense in the liver to counteract the Cd hepatoxicity, especially in the F strain. Activation of ER stress response positively stimulated the autophagy, then triggering apoptosis in fish after dietary Cd exposure. Thus, Cd-induced autophagy served as a protective strategy to alleviate hepatoxicity, but overaction of ER stress also triggered irreparable cell death via apoptosis. Cd induced dysregulation of lipid accumulation, which might be a common mechanism in response to hepatoxicity. Last but not least, the F strain showed stronger response on antioxidant, ER stress and autophagy, but apoptosis were remitted compared with the A strain, implying the F strain showed stronger response but better defense strategies to dietary Cd exposure. Our finding provides useful information for genetic breeding in aquaculture, and ultimately contribute to the safety assessment of aquatic products for human consumption. (C) 2020 Elsevier Ltd. All rights reserved.
WOS关键词ENDOPLASMIC-RETICULUM STRESS ; HEPATIC LIPID-METABOLISM ; OXIDATIVE STRESS ; METAL ACCUMULATION ; ANTIOXIDANT RESPONSES ; CALCIUM HOMEOSTASIS ; AUTOPHAGY ; LIVER ; EXPOSURE ; ACTIVATION
资助项目National Natural Science Foundation of China[U19A2041] ; National Natural Science Foundation of China[31972805] ; National Key R&D Program of China[2018YFD0900605] ; National Key R&D Program of China[2019YFD0900200] ; China Agriculture Research System[CARS-45-09] ; Science and Technology Service Network Initiative[Y82Z131201]
WOS研究方向Environmental Sciences & Ecology
语种英语
出版者PERGAMON-ELSEVIER SCIENCE LTD
WOS记录号WOS:000581030700012
资助机构National Natural Science Foundation of China ; National Natural Science Foundation of China ; National Natural Science Foundation of China ; National Natural Science Foundation of China ; National Key R&D Program of China ; National Key R&D Program of China ; National Key R&D Program of China ; National Key R&D Program of China ; China Agriculture Research System ; China Agriculture Research System ; China Agriculture Research System ; China Agriculture Research System ; Science and Technology Service Network Initiative ; Science and Technology Service Network Initiative ; Science and Technology Service Network Initiative ; Science and Technology Service Network Initiative ; National Natural Science Foundation of China ; National Natural Science Foundation of China ; National Natural Science Foundation of China ; National Natural Science Foundation of China ; National Key R&D Program of China ; National Key R&D Program of China ; National Key R&D Program of China ; National Key R&D Program of China ; China Agriculture Research System ; China Agriculture Research System ; China Agriculture Research System ; China Agriculture Research System ; Science and Technology Service Network Initiative ; Science and Technology Service Network Initiative ; Science and Technology Service Network Initiative ; Science and Technology Service Network Initiative ; National Natural Science Foundation of China ; National Natural Science Foundation of China ; National Natural Science Foundation of China ; National Natural Science Foundation of China ; National Key R&D Program of China ; National Key R&D Program of China ; National Key R&D Program of China ; National Key R&D Program of China ; China Agriculture Research System ; China Agriculture Research System ; China Agriculture Research System ; China Agriculture Research System ; Science and Technology Service Network Initiative ; Science and Technology Service Network Initiative ; Science and Technology Service Network Initiative ; Science and Technology Service Network Initiative ; National Natural Science Foundation of China ; National Natural Science Foundation of China ; National Natural Science Foundation of China ; National Natural Science Foundation of China ; National Key R&D Program of China ; National Key R&D Program of China ; National Key R&D Program of China ; National Key R&D Program of China ; China Agriculture Research System ; China Agriculture Research System ; China Agriculture Research System ; China Agriculture Research System ; Science and Technology Service Network Initiative ; Science and Technology Service Network Initiative ; Science and Technology Service Network Initiative ; Science and Technology Service Network Initiative
源URL[http://ir.ihb.ac.cn/handle/342005/39282]  
专题水生生物研究所_淡水生态学研究中心_期刊论文
通讯作者Jin, Junyan
作者单位1.Univ Chinese Acad Sci, Coll Adv Agr Sci, Beijing 100049, Peoples R China
2.Chinese Acad Sci, Inst Hydrobiol, State Key Lab Freshwater Ecol & Biotechnol, Wuhan 430072, Peoples R China
推荐引用方式
GB/T 7714		 Li, Hongyan,Xu, Wenjie,Wu, Liyun,et al. Distinct dietary cadmium toxic effects and defense strategies in two strains of gibel carp (Carassius gibelio) revealed by a comprehensive perspective[J]. CHEMOSPHERE,2020,261:11.
APA Li, Hongyan.,Xu, Wenjie.,Wu, Liyun.,Dong, Bo.,Jin, Junyan.,...&Xie, Shouqi.(2020).Distinct dietary cadmium toxic effects and defense strategies in two strains of gibel carp (Carassius gibelio) revealed by a comprehensive perspective.CHEMOSPHERE,261,11.
MLA Li, Hongyan,et al."Distinct dietary cadmium toxic effects and defense strategies in two strains of gibel carp (Carassius gibelio) revealed by a comprehensive perspective".CHEMOSPHERE 261(2020):11.

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来源：水生生物研究所

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