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Chinese Academy of Sciences Institutional Repositories Grid
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  2. 水生生物研究所
  3. 中科院水生所知识产出（2009年前）
  4. 水生生物分子与细胞生物学研究中心
  5. 期刊论文
Grass Carp Reovirus (GCRV) Giving Its All to Suppress IFN Production by Countering MAVS Signaling Transduction

文献类型：期刊论文

作者Lu, Long-Feng3,4; Li, Zhuo-Cong3,4; Zhang, Can3,4; Zhou, Xiao-Yu2,4; Zhou, Yu3,4; Jiang, Jing-Yu3,4; Chen, Dan-Dan3,4; Li, Shun3,4; Zhang, Yong-An1,4
刊名FRONTIERS IN IMMUNOLOGY
出版日期2020-10-26
卷号11页码:15
关键词GCRV viral proteins immune evasion MAVS interferon
ISSN号1664-3224
DOI10.3389/fimmu.2020.545302
通讯作者Li, Shun(bob@ihb.ac.cn) ; Zhang, Yong-An(yonganzhang@mail.hzau.edu.cn)
英文摘要Viruses typically target host RIG-I-like receptors (RLRs), a group of key factors involved in interferon (IFN) production, to enhance viral infection. To date, though immune evasion methods to contradict IFN production have been characterized for a series of terrestrial viruses, the strategies employed by fish viruses remain unclear. Here, we report that all grass carp reovirus (GCRV) proteins encoded by segments S1 to S11 suppress mitochondrial antiviral signaling protein (MAVS)-mediated IFN expression. First, the GCRV viral proteins blunted the MAVS-induced expression of IFN, and impair MAVS antiviral capacity significantly. Interestingly, subsequent co-immunoprecipitation experiments demonstrated that all GCRV viral proteins interacted with several RLR cascades, especially with TANK-binding kinase 1 (TBK1) which was the downstream factor of MAVS. To further illustrate the mechanisms of these interactions between GCRV viral proteins and host RLRs, two of the viral proteins, NS79 (S4) and VP3 (S3), were selected as representative proteins for two distinguished mechanisms. The obtained data demonstrated that NS79 was phosphorylated by gcTBK1, leading to the reduction of host substrate gcIRF3/7 phosphorylation. On the other hand, VP3 degraded gcMAVS and the degradation was significantly reversed by 3-MA. The biological effects of both NS79 and VP3 were consistently found to be related to the suppression of IFN expression and the promotion of viral evasion. Our findings shed light on the special evasion mechanism utilized by fish virus through IFN regulation, which might differ between fish and mammals.
WOS关键词NF-KAPPA-B ; INNATE IMMUNE-RESPONSE ; ADAPTER PROTEIN ; GENE-EXPRESSION ; INTERFERON ; VIRUS ; TBK1 ; IDENTIFICATION ; INDUCTION ; PHOSPHORYLATION
资助项目National Key Research and Development Program of China[2018YFD0900504] ; National Natural Science Foundation of China[31725026] ; National Natural Science Foundation of China[31802338] ; Science Fund for Creative Research Groups of the Natural Science Foundation of Hubei Province of China[2018CFA011] ; Youth Innovation Promotion Association
WOS研究方向Immunology
语种英语
WOS记录号WOS:000587376100001
出版者FRONTIERS MEDIA SA
资助机构National Key Research and Development Program of China ; National Key Research and Development Program of China ; National Key Research and Development Program of China ; National Key Research and Development Program of China ; National Natural Science Foundation of China ; National Natural Science Foundation of China ; National Natural Science Foundation of China ; National Natural Science Foundation of China ; Science Fund for Creative Research Groups of the Natural Science Foundation of Hubei Province of China ; Science Fund for Creative Research Groups of the Natural Science Foundation of Hubei Province of China ; Science Fund for Creative Research Groups of the Natural Science Foundation of Hubei Province of China ; Science Fund for Creative Research Groups of the Natural Science Foundation of Hubei Province of China ; Youth Innovation Promotion Association ; Youth Innovation Promotion Association ; Youth Innovation Promotion Association ; Youth Innovation Promotion Association ; National Key Research and Development Program of China ; National Key Research and Development Program of China ; National Key Research and Development Program of China ; National Key Research and Development Program of China ; National Natural Science Foundation of China ; National Natural Science Foundation of China ; National Natural Science Foundation of China ; National Natural Science Foundation of China ; Science Fund for Creative Research Groups of the Natural Science Foundation of Hubei Province of China ; Science Fund for Creative Research Groups of the Natural Science Foundation of Hubei Province of China ; Science Fund for Creative Research Groups of the Natural Science Foundation of Hubei Province of China ; Science Fund for Creative Research Groups of the Natural Science Foundation of Hubei Province of China ; Youth Innovation Promotion Association ; Youth Innovation Promotion Association ; Youth Innovation Promotion Association ; Youth Innovation Promotion Association ; National Key Research and Development Program of China ; National Key Research and Development Program of China ; National Key Research and Development Program of China ; National Key Research and Development Program of China ; National Natural Science Foundation of China ; National Natural Science Foundation of China ; National Natural Science Foundation of China ; National Natural Science Foundation of China ; Science Fund for Creative Research Groups of the Natural Science Foundation of Hubei Province of China ; Science Fund for Creative Research Groups of the Natural Science Foundation of Hubei Province of China ; Science Fund for Creative Research Groups of the Natural Science Foundation of Hubei Province of China ; Science Fund for Creative Research Groups of the Natural Science Foundation of Hubei Province of China ; Youth Innovation Promotion Association ; Youth Innovation Promotion Association ; Youth Innovation Promotion Association ; Youth Innovation Promotion Association ; National Key Research and Development Program of China ; National Key Research and Development Program of China ; National Key Research and Development Program of China ; National Key Research and Development Program of China ; National Natural Science Foundation of China ; National Natural Science Foundation of China ; National Natural Science Foundation of China ; National Natural Science Foundation of China ; Science Fund for Creative Research Groups of the Natural Science Foundation of Hubei Province of China ; Science Fund for Creative Research Groups of the Natural Science Foundation of Hubei Province of China ; Science Fund for Creative Research Groups of the Natural Science Foundation of Hubei Province of China ; Science Fund for Creative Research Groups of the Natural Science Foundation of Hubei Province of China ; Youth Innovation Promotion Association ; Youth Innovation Promotion Association ; Youth Innovation Promotion Association ; Youth Innovation Promotion Association
源URL[http://ir.ihb.ac.cn/handle/342005/39292]  
专题水生生物研究所_水生生物分子与细胞生物学研究中心_期刊论文
通讯作者Li, Shun; Zhang, Yong-An
作者单位1.Huazhong Agr Univ, Coll Fisheries, Wuhan, Peoples R China
2.Dalian Ocean Univ, Coll Fisheries & Life Sci, Dalian, Peoples R China
3.Univ Chinese Acad Sci, Coll Adv Agr Sci, Beijing, Peoples R China
4.Chinese Acad Sci, Inst Hydrobiol, Wuhan, Peoples R China
推荐引用方式
GB/T 7714		 Lu, Long-Feng,Li, Zhuo-Cong,Zhang, Can,et al. Grass Carp Reovirus (GCRV) Giving Its All to Suppress IFN Production by Countering MAVS Signaling Transduction[J]. FRONTIERS IN IMMUNOLOGY,2020,11:15.
APA Lu, Long-Feng.,Li, Zhuo-Cong.,Zhang, Can.,Zhou, Xiao-Yu.,Zhou, Yu.,...&Zhang, Yong-An.(2020).Grass Carp Reovirus (GCRV) Giving Its All to Suppress IFN Production by Countering MAVS Signaling Transduction.FRONTIERS IN IMMUNOLOGY,11,15.
MLA Lu, Long-Feng,et al."Grass Carp Reovirus (GCRV) Giving Its All to Suppress IFN Production by Countering MAVS Signaling Transduction".FRONTIERS IN IMMUNOLOGY 11(2020):15.

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来源：水生生物研究所

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