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Bacteria-Derived Hemolysis-Related Genes Widely Exist in Scuticociliates

文献类型：期刊论文

作者Zhang, Jing4,5,6,7; Chen, Kai6; Jiang, Chuanqi4,5,6,7; Yang, Wentao6; Gu, Siyu3,6; Wang, Guangying6; Lu, Yishan6,7; Miao, Wei1,2,6; Xiong, Jie6
刊名MICROORGANISMS
出版日期2020-11-01
卷号8期号:11页码:13
关键词scuticociliatosis Uronema marinum MAC genome hemolysis-III like protein
DOI10.3390/microorganisms8111838
通讯作者Xiong, Jie(xiongjie@ihb.ac.cn)
英文摘要Scuticociliatosis is an invasive external or systemic infection caused by ciliated protozoa, mainly those within the subclass Scuticociliatia (scuticociliates). Many scuticociliates are fish pathogens, including Miamiensis avidus, Philasterides dicentrarchi, Pseudocohnilembus persalinus, and Uronema marinum. Our previous study showed that hemolysis-related genes derived from bacteria through horizontal gene transfer (HGT) may contribute to virulence in P. persalinus. Hemorrhagic lesions are a common feature of scuticociliatosis, but it is not known whether other scuticociliates also have bacteria-derived hemolysis-related genes. In this study, we constructed a high-quality macronuclear genome of another typical pathogenic scuticociliate, U. marinum. A total of 105 HGT genes were identified in this species, of which 35 were homologs of hemolysis-related genes (including hemolysin-like genes) that had previously been identified in P. persalinus. Sequencing of an additional five species from four scuticociliate families showed that bacteria-derived hemolysis-related genes (especially hemolysin-like genes) are widely distributed in scuticociliates. Based on these findings, we suggest that hemolysin-like genes may have originated before the divergence of scuticociliates.
WOS关键词PHILASTERIDES-DICENTRARCHI CILIOPHORA ; GENOME ; HISTOPATHOLOGY ; EXPRESSION ; INFECTION ; ALIGNMENT ; TAXONOMY ; SEQUENCE ; INSIGHTS ; PROTOZOA
资助项目National Natural Science Foundation of China[31525021] ; National Natural Science Foundation of China[91631303] ; National Natural Science Foundation of China[31672281] ; National Natural Science Foundation of China[31872221] ; Natural Science Foundation of Hubei Province[2019CFB808] ; Shenzhen Science and Technology Project[JCYJ20180507183240459] ; China Postdoctoral Science Foundation[2019M652735] ; China Postdoctoral Science Foundation[2020M682528]
WOS研究方向Microbiology
语种英语
WOS记录号WOS:000593170100001
出版者MDPI
资助机构National Natural Science Foundation of China ; National Natural Science Foundation of China ; National Natural Science Foundation of China ; National Natural Science Foundation of China ; Natural Science Foundation of Hubei Province ; Natural Science Foundation of Hubei Province ; Natural Science Foundation of Hubei Province ; Natural Science Foundation of Hubei Province ; Shenzhen Science and Technology Project ; Shenzhen Science and Technology Project ; Shenzhen Science and Technology Project ; Shenzhen Science and Technology Project ; China Postdoctoral Science Foundation ; China Postdoctoral Science Foundation ; China Postdoctoral Science Foundation ; China Postdoctoral Science Foundation ; National Natural Science Foundation of China ; National Natural Science Foundation of China ; National Natural Science Foundation of China ; National Natural Science Foundation of China ; Natural Science Foundation of Hubei Province ; Natural Science Foundation of Hubei Province ; Natural Science Foundation of Hubei Province ; Natural Science Foundation of Hubei Province ; Shenzhen Science and Technology Project ; Shenzhen Science and Technology Project ; Shenzhen Science and Technology Project ; Shenzhen Science and Technology Project ; China Postdoctoral Science Foundation ; China Postdoctoral Science Foundation ; China Postdoctoral Science Foundation ; China Postdoctoral Science Foundation ; National Natural Science Foundation of China ; National Natural Science Foundation of China ; National Natural Science Foundation of China ; National Natural Science Foundation of China ; Natural Science Foundation of Hubei Province ; Natural Science Foundation of Hubei Province ; Natural Science Foundation of Hubei Province ; Natural Science Foundation of Hubei Province ; Shenzhen Science and Technology Project ; Shenzhen Science and Technology Project ; Shenzhen Science and Technology Project ; Shenzhen Science and Technology Project ; China Postdoctoral Science Foundation ; China Postdoctoral Science Foundation ; China Postdoctoral Science Foundation ; China Postdoctoral Science Foundation ; National Natural Science Foundation of China ; National Natural Science Foundation of China ; National Natural Science Foundation of China ; National Natural Science Foundation of China ; Natural Science Foundation of Hubei Province ; Natural Science Foundation of Hubei Province ; Natural Science Foundation of Hubei Province ; Natural Science Foundation of Hubei Province ; Shenzhen Science and Technology Project ; Shenzhen Science and Technology Project ; Shenzhen Science and Technology Project ; Shenzhen Science and Technology Project ; China Postdoctoral Science Foundation ; China Postdoctoral Science Foundation ; China Postdoctoral Science Foundation ; China Postdoctoral Science Foundation
源URL[http://ir.ihb.ac.cn/handle/342005/39354]  
专题水生生物研究所_水生生物分子与细胞生物学研究中心_期刊论文
通讯作者Xiong, Jie
作者单位1.CAS Ctr Excellence Anim Evolut & Genet, Kunming 650223, Yunnan, Peoples R China
2.State Key Lab Freshwater Ecol & Biotechnol China, Wuhan 430072, Peoples R China
3.Univ Chinese Acad Sci, Beijing 100049, Peoples R China
4.Shenzhen Dapeng New Dist Sci & Technol Innovat Se, Shenzhen 518119, Peoples R China
5.Guangdong Prov Engn Res Ctr Aquat Anim Hlth Asses, Shenzhen 518120, Peoples R China
6.Chinese Acad Sci, Inst Hydrobiol, Key Lab Aquat Biodivers & Conservat, Wuhan 430072, Peoples R China
7.Guangdong Ocean Univ, Shenzhen Inst, Shenzhen 518120, Peoples R China
推荐引用方式
GB/T 7714		 Zhang, Jing,Chen, Kai,Jiang, Chuanqi,et al. Bacteria-Derived Hemolysis-Related Genes Widely Exist in Scuticociliates[J]. MICROORGANISMS,2020,8(11):13.
APA Zhang, Jing.,Chen, Kai.,Jiang, Chuanqi.,Yang, Wentao.,Gu, Siyu.,...&Xiong, Jie.(2020).Bacteria-Derived Hemolysis-Related Genes Widely Exist in Scuticociliates.MICROORGANISMS,8(11),13.
MLA Zhang, Jing,et al."Bacteria-Derived Hemolysis-Related Genes Widely Exist in Scuticociliates".MICROORGANISMS 8.11(2020):13.

入库方式： OAI收割

来源：水生生物研究所

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