IRF11 regulates positively type I IFN transcription and antiviral response in mandarin fish, Siniperca chuatsi
文献类型：期刊论文
| 作者 | Li, Li3,4; Chen, Shan Nan3,4; Nie, P.1,2,3,4 |
| 刊名 | DEVELOPMENTAL AND COMPARATIVE IMMUNOLOGY
 |
| 出版日期 | 2021 |
| 卷号 | 114页码:7 |
| 关键词 | IRF11 IFN Type I IFN ISRE Transcription Rhabdovirus Siniperca chuatsi Mandarin fish |
| ISSN号 | 0145-305X |
| DOI | 10.1016/j.dci.2020.103846 |
| 通讯作者 | Nie, P.(pinnie@ihb.ac.cn) |
| 英文摘要 | In vertebrates, a total of eleven interferon (IFN) regulatory factors (IRFs), IRF1 to IRF11 are reported, with the conserved presence of IRF1 to IRF9 in all classes of vertebrates. However, IRF10 has been reported only in fish and birds, and IRF11 seems to be a fish specific IRF member. In this study, IRF11 in mandarin fish Siniperca chuatsi was found upregulated following virus infection, and IRF11 was localized constitutively in nucleus as revealed through immunofluorescence test. The overexpression and/or luciferase reporter assays showed that IRF11 can induce transcriptionally the ISRE activity, and the expression of type I IFNs, IFNc and IFNh, as well as the IFN-stimulated gene, Mx, thus inhibiting the Siniperca chuatsi rhabdovirus (SCRV) replication as indicated in the reduced expression of virus protein genes. It is thus suggested that IRF11 in mandarin fish and probably in other teleost fish can exert its antiviral effect through the upregulation of type I IFNs and ISGs. |
| WOS关键词 | CONSTITUTIVE EXPRESSION ; ZEBRAFISH IRF1 ; PERCIFORM FISH ; INTERFERON ; REVEALS ; FAMILY ; GENES ; ACTIVATION ; INDUCTION ; IFN-PHI-1 |
| 资助项目 | National Key Research and Development Program of China[2018YFD0900501] ; China Agriculture Research System[CARS-46] ; special top talent plan One Thing One Decision programme in Shandong Province, China[(2018)27] ; special top talent plan First Class Fishery Discipline programme in Shandong Province, China[(2018)8] |
| WOS研究方向 | Fisheries ; Immunology ; Zoology |
| 语种 | 英语 |
| WOS记录号 | WOS:000588061100040 |
| 出版者 | ELSEVIER SCI LTD |
| 资助机构 | National Key Research and Development Program of China ; National Key Research and Development Program of China ; National Key Research and Development Program of China ; National Key Research and Development Program of China ; China Agriculture Research System ; China Agriculture Research System ; China Agriculture Research System ; China Agriculture Research System ; special top talent plan One Thing One Decision programme in Shandong Province, China ; special top talent plan One Thing One Decision programme in Shandong Province, China ; special top talent plan One Thing One Decision programme in Shandong Province, China ; special top talent plan One Thing One Decision programme in Shandong Province, China ; special top talent plan First Class Fishery Discipline programme in Shandong Province, China ; special top talent plan First Class Fishery Discipline programme in Shandong Province, China ; special top talent plan First Class Fishery Discipline programme in Shandong Province, China ; special top talent plan First Class Fishery Discipline programme in Shandong Province, China ; National Key Research and Development Program of China ; National Key Research and Development Program of China ; National Key Research and Development Program of China ; National Key Research and Development Program of China ; China Agriculture Research System ; China Agriculture Research System ; China Agriculture Research System ; China Agriculture Research System ; special top talent plan One Thing One Decision programme in Shandong Province, China ; special top talent plan One Thing One Decision programme in Shandong Province, China ; special top talent plan One Thing One Decision programme in Shandong Province, China ; special top talent plan One Thing One Decision programme in Shandong Province, China ; special top talent plan First Class Fishery Discipline programme in Shandong Province, China ; special top talent plan First Class Fishery Discipline programme in Shandong Province, China ; special top talent plan First Class Fishery Discipline programme in Shandong Province, China ; special top talent plan First Class Fishery Discipline programme in Shandong Province, China ; National Key Research and Development Program of China ; National Key Research and Development Program of China ; National Key Research and Development Program of China ; National Key Research and Development Program of China ; China Agriculture Research System ; China Agriculture Research System ; China Agriculture Research System ; China Agriculture Research System ; special top talent plan One Thing One Decision programme in Shandong Province, China ; special top talent plan One Thing One Decision programme in Shandong Province, China ; special top talent plan One Thing One Decision programme in Shandong Province, China ; special top talent plan One Thing One Decision programme in Shandong Province, China ; special top talent plan First Class Fishery Discipline programme in Shandong Province, China ; special top talent plan First Class Fishery Discipline programme in Shandong Province, China ; special top talent plan First Class Fishery Discipline programme in Shandong Province, China ; special top talent plan First Class Fishery Discipline programme in Shandong Province, China ; National Key Research and Development Program of China ; National Key Research and Development Program of China ; National Key Research and Development Program of China ; National Key Research and Development Program of China ; China Agriculture Research System ; China Agriculture Research System ; China Agriculture Research System ; China Agriculture Research System ; special top talent plan One Thing One Decision programme in Shandong Province, China ; special top talent plan One Thing One Decision programme in Shandong Province, China ; special top talent plan One Thing One Decision programme in Shandong Province, China ; special top talent plan One Thing One Decision programme in Shandong Province, China ; special top talent plan First Class Fishery Discipline programme in Shandong Province, China ; special top talent plan First Class Fishery Discipline programme in Shandong Province, China ; special top talent plan First Class Fishery Discipline programme in Shandong Province, China ; special top talent plan First Class Fishery Discipline programme in Shandong Province, China |
| 源URL | [http://ir.ihb.ac.cn/handle/342005/39249]  |
| 专题 | 水生生物研究所_鱼类生物学及渔业生物技术研究中心_期刊论文 |
| 通讯作者 | Nie, P. |
| 作者单位 | 1.Qingdao Agr Univ, Sch Marine Sci & Engn, Qingdao 266109, Shandong, Peoples R China 2.Pilot Natl Lab Marine Sci & Technol Qingdao, Lab Marine Biol & Biotechnol, Qingdao 266237, Shandong, Peoples R China 3.Chinese Acad Sci, Inst Hydrobiol, Key Lab Aquaculture Dis Control, Wuhan 430072, Hubei, Peoples R China 4.Chinese Acad Sci, Inst Hydrobiol, State Key Lab Freshwater Ecol & Biotechnol, Wuhan 430072, Hubei, Peoples R China |
| 推荐引用方式 GB/T 7714 | Li, Li,Chen, Shan Nan,Nie, P.. IRF11 regulates positively type I IFN transcription and antiviral response in mandarin fish, Siniperca chuatsi[J]. DEVELOPMENTAL AND COMPARATIVE IMMUNOLOGY,2021,114:7. |
| APA | Li, Li,Chen, Shan Nan,&Nie, P..(2021).IRF11 regulates positively type I IFN transcription and antiviral response in mandarin fish, Siniperca chuatsi.DEVELOPMENTAL AND COMPARATIVE IMMUNOLOGY,114,7. |
| MLA | Li, Li,et al."IRF11 regulates positively type I IFN transcription and antiviral response in mandarin fish, Siniperca chuatsi".DEVELOPMENTAL AND COMPARATIVE IMMUNOLOGY 114(2021):7. |
入库方式： OAI收割
来源：水生生物研究所
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