Astaxanthin and its Effects in Inflammatory Responses and Inflammation-Associated Diseases: Recent Advances and Future Directions
文献类型：期刊论文
| 作者 | Chang, Ming Xian1,2,3; Xiong, Fan3 |
| 刊名 | MOLECULES
 |
| 出版日期 | 2020-11-01 |
| 卷号 | 25期号:22页码:14 |
| 关键词 | astaxanthin oxidative stress anti-inflammatory inflammation-associated diseases |
| DOI | 10.3390/molecules25225342 |
| 通讯作者 | Chang, Ming Xian(mingxianchang@ihb.ac.cn) |
| 英文摘要 | Astaxanthin is a natural lipid-soluble and red-orange carotenoid. Due to its strong antioxidant property, anti-inflammatory, anti-apoptotic, and immune modulation, astaxanthin has gained growing interest as a multi-target pharmacological agent against various diseases. In the current review, the anti-inflammation mechanisms of astaxanthin involved in targeting for inflammatory biomarkers and multiple signaling pathways, including PI3K/AKT, Nrf2, NF-kappa B, ERK1/2, JNK, p38 MAPK, and JAK-2/STAT-3, have been described. Furthermore, the applications of anti-inflammatory effects of astaxanthin in neurological diseases, diabetes, gastrointestinal diseases, hepatic and renal diseases, eye and skin disorders, are highlighted. In addition to the protective effects of astaxanthin in various chronic and acute diseases, we also summarize recent advances for the inconsistent roles of astaxanthin in infectious diseases, and give our view that the exact function of astaxanthin in response to different pathogen infection and the potential protective effects of astaxanthin in viral infectious diseases should be important research directions in the future. |
| WOS关键词 | ACID-ACYLATED ASTAXANTHIN ; OXIDATIVE STRESS ; DIETARY ASTAXANTHIN ; TRANS-ASTAXANTHIN ; SIGNALING PATHWAY ; INTERFERON-GAMMA ; MICE ; DEFICITS ; INJURY ; ACTIVATION |
| WOS研究方向 | Biochemistry & Molecular Biology ; Chemistry |
| 语种 | 英语 |
| WOS记录号 | WOS:000594142700001 |
| 出版者 | MDPI |
| 源URL | [http://ir.ihb.ac.cn/handle/342005/39422]  |
| 专题 | 水生生物研究所_鱼类生物学及渔业生物技术研究中心_期刊论文 |
| 通讯作者 | Chang, Ming Xian |
| 作者单位 | 1.Univ Chinese Acad Sci, Beijing 100049, Peoples R China 2.Chinese Acad Sci, Innovat Acad Seed Design, Wuhan 430072, Peoples R China 3.Chinese Acad Sci, State Key Lab Freshwater Ecol & Biotechnol, Key Lab Aquaculture Dis Control, Inst Hydrobiol, Wuhan 430072, Peoples R China |
| 推荐引用方式 GB/T 7714 | Chang, Ming Xian,Xiong, Fan. Astaxanthin and its Effects in Inflammatory Responses and Inflammation-Associated Diseases: Recent Advances and Future Directions[J]. MOLECULES,2020,25(22):14. |
| APA | Chang, Ming Xian,&Xiong, Fan.(2020).Astaxanthin and its Effects in Inflammatory Responses and Inflammation-Associated Diseases: Recent Advances and Future Directions.MOLECULES,25(22),14. |
| MLA | Chang, Ming Xian,et al."Astaxanthin and its Effects in Inflammatory Responses and Inflammation-Associated Diseases: Recent Advances and Future Directions".MOLECULES 25.22(2020):14. |
入库方式： OAI收割
来源：水生生物研究所
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