Accurately delineating the subsurface structures, lithologies and pore fluids is a prevalent procedure in reservoir characterisation. Subsurface structures are deciphered on the basis of seismic reflection data. However, seismic data on its own is inadequate to accurately mark fluid heterogeneities of pores buried in the subsurface. In this research, the integrated strategy of seismic interpretation, rock physics modelling and fluid substitution scrutiny has been conducted to exemplify the reservoir potential of the Missa Keswal area of Pakistan. Seismic data interpretation revealed that Eocene limestone is a prospective reservoir in the study area. Structural interpretation reveals a compressional regime with the presence of a pop-up structure restricted by thrusts on either sides, which is appropriate for hydrocarbon accumulation. In addition, instantaneous amplitude affirms the recognition of foremost lithological changes and discontinuities. Anomalous regions were identified by bulk modulus and Poisson ratio which are indicators of valuable rock physics parameters. Gassmann fluid substitution performed at Eocene level implies discrepancy in acoustic properties at diverse levels of water saturation. The presented integration approach can be applied to assess reservoir potential in any sedimentary basin of the world with available conventional data.