The pyrochlore-type MgZrSi₂O₇ has been investigated by in situ synchrotron energy-dispersive X-ray diffraction measurements up 24.3 GPa at room temperature in a multianvil high pressure apparatus. The pressure has been calculated using an internal gold metal pressure calibrant. No phase transformation was observed in this study. A third-order Birch–Murnaghan equation of state was used to fit the pressure–volume data. The fitting gives a volume of V ₀=802.8±0.2 Å³, an isothermal bulk modulus of K _T =249±12 GPa, and first pressure derivative of K′ _T =3.2±1.3. If K′ _T is fixed as 4, K _T is obtained as 241.8±2.6 GPa. Compared with zirconate or titanate pyrochlores, MgZrSi₂O₇ shows a smaller compressibility due to a larger cation radii ratio (r _{Mg,  Zr} /r _Si).