Aberrant Hippocampal Functional Connectivity Is Associated with Fornix White Matter Integrity in Alzheimer's Disease and Mild Cognitive Impairment
文献类型：期刊论文
| 作者 | Wang, Pan1,2 ; Zhou, Bo2; Yao, Hongxiang3; Sangma, Xie4,5,9; Feng, Feng2; Zhang, Zengqiang6; Guo, Yan'e2; An, Ningyu3; Zhou, Yuying1; Zhang, Xi2
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| 刊名 | JOURNAL OF ALZHEIMERS DISEASE
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| 出版日期 | 2020 |
| 卷号 | 75期号:4页码:1153-1168 |
| ISSN号 | 1387-2877 |
| 关键词 | Alzheimer's disease fornix functional connectivity hippocampus mild cognitive impairment white matter integrity |
| DOI | 10.3233/JAD-200066 |
| 通讯作者 | Zhou, Yuying(qiying789@sina.cn) ; Zhang, Xi(zhangxi@301hospital.com.cn) ; Yong, Liu(yliu@nlpr.ia.ac.cn) |
| 英文摘要 | Background: Alzheimer's disease (AD) is the most common cause of dementia in older individuals, and amnestic mild cognitive impairment (aMCI) is currently considered the prodromal stage of AD. The hippocampus and fornix interact functionally and structurally, with the fornix being the major efferent white matter tract from the hippocampus. Objective: The main aim of this study was to examine the impairments present in subjects with AD or aMCI and the relationship of these impairments with the microstructure of the fornix and the functional connectivity (FC) and gray matter volume of the hippocampus. Methods: Forty-four AD, 34 aMCI, and 41 age- and gender-matched normal controls (NCs) underwent neuropsychological assessments and multimode MRI. We chose the bilateral hippocampi as the region of interest in which gray matter alterations and FC with the whole brain were assessed and the fornix body as the region of interest in which the microstructural integrity of the white matter was observed. We also evaluated the relationship among gray matter alterations, the abnormal FC of the hippocampus and the integrity of the fornix in AD/aMCI. Results: Compared to the NC group, the AD and aMCI groups demonstrated decreased gray matter volume, reduced FC between the bilateral hippocampi and several brain regions in the default mode network and control network, and damaged integrity of the fornix body (decreased fractional anisotropy and increased diffusivity). We also found that left hippocampal FC with some regions, the integrity of the fornix body, and cognition ability were significantly correlated. Therefore, our findings suggest that damage to white matter integrity may partially explain the reduced resting-state FC of the hippocampus in AD and aMCI. Conclusion: AD and aMCI are diseases of disconnectivity including not only functional but also structural disconnectivity. Damage to white matter integrity may partially explain the reduced resting-state FC in AD and aMCI. These findings have significant implications for diagnostics and modeling and provide insights for understanding the disconnection syndrome in AD. |
| WOS关键词 | ALTERED SPONTANEOUS ACTIVITY ; RESTING-STATE NETWORKS ; TENSOR IMAGING DETECTS ; DEFAULT-MODE NETWORK ; NATIONAL INSTITUTE ; STRUCTURAL CONNECTIVITY ; DIAGNOSTIC GUIDELINES ; POSTERIOR CINGULATE ; MEMORY PERFORMANCE ; RESEARCH FRAMEWORK |
| 资助项目 | National Key Research and Development Program of China[2018YFC2001700] ; National Natural Science Foundation of China[81871438] ; National Natural Science Foundation of China[81901101] ; National Natural Science Foundation of China[81871398] ; National Natural Science Foundation of China[81471120] ; Chinese Academy of Sciences[XDBS01020200] ; Natural Science Foundation of Tianjin[19JCQNJC10400] ; Beijing Municipal Science & Technology Commission[Z171100000117001] |
| WOS研究方向 | Neurosciences & Neurology |
| 语种 | 英语 |
| 出版者 | IOS PRESS |
| WOS记录号 | WOS:000550022100008 |
| 资助机构 | National Key Research and Development Program of China ; National Natural Science Foundation of China ; Chinese Academy of Sciences ; Natural Science Foundation of Tianjin ; Beijing Municipal Science & Technology Commission |
| 源URL | [http://ir.ia.ac.cn/handle/173211/40153]  |
| 专题 | 自动化研究所_脑网络组研究中心 |
| 通讯作者 | Zhou, Yuying; Zhang, Xi; Yong, Liu |
| 作者单位 | 1.Nankai Univ, Tianjin Huanhu Hosp, Dept Neurol, Tianjin 300350, Peoples R China 2.Chinese Peoples Liberat Army Gen Hosp, Med Ctr 2, Natl Clin Res Ctr Geriatr Dis, Dept Neurol, Beijing, Peoples R China 3.Chinese Peoples Liberat Army Gen Hosp, Med Ctr 2, Natl Clin Res Ctr Geriatr Dis, Dept Radiol, Beijing, Peoples R China 4.Chinese Acad Sci, Inst Automat, Brainnetome Ctr, Beijing 100190, Peoples R China 5.Chinese Acad Sci, Inst Automat, Natl Lab Pattern Recognit, Beijing, Peoples R China 6.Chinese Peoples Liberat Army Gen Hosp, Hainan Hosp, Sanya, Peoples R China 7.Chinese Acad Sci, Inst Automat, CAS Ctr Excellence Brain Sci & Intelligence Techn, Beijing, Peoples R China 8.Univ Chinese Acad Sci, Sch Artificial Intelligence, Beijing, Peoples R China 9.Hangzhou Dianzi Univ, Coll Life Informat Sci & Instrument Engn, Hangzhou, Peoples R China |
| 推荐引用方式 GB/T 7714 | Wang, Pan,Zhou, Bo,Yao, Hongxiang,et al. Aberrant Hippocampal Functional Connectivity Is Associated with Fornix White Matter Integrity in Alzheimer's Disease and Mild Cognitive Impairment[J]. JOURNAL OF ALZHEIMERS DISEASE,2020,75(4):1153-1168. |
| APA | Wang, Pan.,Zhou, Bo.,Yao, Hongxiang.,Sangma, Xie.,Feng, Feng.,...&Yong, Liu.(2020).Aberrant Hippocampal Functional Connectivity Is Associated with Fornix White Matter Integrity in Alzheimer's Disease and Mild Cognitive Impairment.JOURNAL OF ALZHEIMERS DISEASE,75(4),1153-1168. |
| MLA | Wang, Pan,et al."Aberrant Hippocampal Functional Connectivity Is Associated with Fornix White Matter Integrity in Alzheimer's Disease and Mild Cognitive Impairment".JOURNAL OF ALZHEIMERS DISEASE 75.4(2020):1153-1168. |
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来源：自动化研究所
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