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Reperfusion plus Selective Intra-arterial Cooling (SI-AC) Improve Recovery in a Nonhuman Primate Model of Stroke

文献类型：期刊论文

作者Wu, Di1,2,3,4; Fu, Yongjuan5; Wu, Longfei1,2; Huber, Mitchell6; Chen, Jian7; Yao, Tianqi1,2; Zhang, Mo8; Wu, Chuanjie1,2; Song, Ming9; He, Xiaoduo1,2
刊名NEUROTHERAPEUTICS
出版日期2020-07-24
页码9
ISSN号1933-7213
关键词Stroke recovery hypothermia white matter diffusion tensor imaging rhesus monkey
DOI10.1007/s13311-020-00895-6
通讯作者Ji, Xunming(jixm@ccmu.edu.cn)
英文摘要Early reperfusion is increasingly prioritized in ischemic stroke care, but outcomes remain suboptimal. Therefore, there is an urgent need to find neuroprotective approaches that can be combined with reperfusion to maximize efficacy. Here, the neuroprotective mechanisms behind therapeutic hypothermia were evaluated in a monkey model of ischemic stroke. Focal ischemia was induced in adult rhesus monkeys by placing autologous clots in the middle cerebral artery. Monkeys were treated with tissue plasminogen activator (t-PA) alone or t-PA plus selective intra-arterial cooling (SI-AC). Serial MRI scans and functional deficit were evaluated after ischemia. Histopathology and immunohistochemistry analysis were performed after the final MRI scan. t-PA plus SI-AC treatment led to a higher rate of MRI tissue rescue, and significantly improved neurologic deficits and daily activity scores compared with t-PA alone. In peri-infarct areas, higher fractional anisotropy values and greater fiber numbers were observed in models receiving t-PA plus SI-AC. Histological findings indicated that myelin damage, spheroids, and spongiosis were significantly ameliorated in models receiving SI-AC treatment. White matter integrity was also improved by SI-AC based on immunochemical staining. Our study demonstrates that SI-AC can be effectively combined with t-PA to improve both structural and functional recovery in a monkey model of focal ischemia. These findings provide proof-of-concept that it may be feasible to add neuroprotective agents as adjunctive treatments to reperfusion therapy for stroke.
WOS关键词ACUTE ISCHEMIC-STROKE ; DIFFUSION ; NEUROPROTECTION ; HYPOTHERMIA ; TRANSIENT ; INFUSION ; INJURY ; MRI
资助项目National Natural Science Foundation of China[81871022] ; National Natural Science Foundation of China[81771260] ; National Natural Science Foundation of China[81620108011] ; National Key R&D Program of China[2017YFC1308401] ; mission talent project of Beijing Municipal Administration of Hospitals[SML20150802] ; Beijing Municipal Science and Technology Project[Z181100001918026] ; Beijing Municipal Administration of Hospitals' Youth Programme[QML20170802]
WOS研究方向Neurosciences & Neurology ; Pharmacology & Pharmacy
语种英语
出版者SPRINGER
WOS记录号WOS:000552159300001
资助机构National Natural Science Foundation of China ; National Key R&D Program of China ; mission talent project of Beijing Municipal Administration of Hospitals ; Beijing Municipal Science and Technology Project ; Beijing Municipal Administration of Hospitals' Youth Programme
源URL[http://ir.ia.ac.cn/handle/173211/40201]  
专题自动化研究所_脑网络组研究中心
通讯作者Ji, Xunming
作者单位1.Capital Med Univ, Xuanwu Hosp, Dept Neurol, Beijing 100053, Peoples R China
2.Capital Med Univ, Xuanwu Hosp, China Amer Inst Neurosci, Beijing 100053, Peoples R China
3.Beijing Key Lab Hypoxia Conditioning Translat Med, Beijing, Peoples R China
4.Beijing Inst Brain Disorders, Ctr Stroke, Beijing, Peoples R China
5.Capital Med Univ, Xuanwu Hosp, Dept Pathol, Beijing 100053, Peoples R China
6.Wayne State Univ, Sch Med, Dept Neurosurg, Detroit, MI USA
7.Capital Med Univ, Xuanwu Hosp, Dept Neurosurg, Beijing 100053, Peoples R China
8.Capital Med Univ, Xuanwu Hosp, Dept Radiol, Beijing 100053, Peoples R China
9.Chinese Acad Sci, Inst Automat, Natl Lab Pattern Recognit, Beijing, Peoples R China
10.Beihang Univ, Beijing Adv Innovat Ctr Big Data Based Precis Med, Sch Biol Sci & Med Engn, Interdisciplinary Innovat Inst Med & Engn, Beijing, Peoples R China
推荐引用方式
GB/T 7714		 Wu, Di,Fu, Yongjuan,Wu, Longfei,et al. Reperfusion plus Selective Intra-arterial Cooling (SI-AC) Improve Recovery in a Nonhuman Primate Model of Stroke[J]. NEUROTHERAPEUTICS,2020:9.
APA Wu, Di.,Fu, Yongjuan.,Wu, Longfei.,Huber, Mitchell.,Chen, Jian.,...&Ji, Xunming.(2020).Reperfusion plus Selective Intra-arterial Cooling (SI-AC) Improve Recovery in a Nonhuman Primate Model of Stroke.NEUROTHERAPEUTICS,9.
MLA Wu, Di,et al."Reperfusion plus Selective Intra-arterial Cooling (SI-AC) Improve Recovery in a Nonhuman Primate Model of Stroke".NEUROTHERAPEUTICS (2020):9.

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来源：自动化研究所

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