Multiscale neurobiological correlates of human neuroticism
文献类型：期刊论文
| 作者 | Xu, Qiang2,3; Liu, Feng2,3 ; Qin, Wen2,3; Jiang, Tianzi1,4; Yu, Chunshui1,2,3
|
| 刊名 | HUMAN BRAIN MAPPING
 |
| 出版日期 | 2020-08-17 |
| 页码 | 14 |
| ISSN号 | 1065-9471 |
| 关键词 | Allen human brain atlas functional connectivity density gene expression neuroticism ventral striatum |
| DOI | 10.1002/hbm.25153 |
| 通讯作者 | Yu, Chunshui(chunshuiyu@tijmu.edu.cn) |
| 英文摘要 | Neuroticism is a heritable personality trait associated with negative emotionality; however, we know little regarding the association between the microscale and macroscale neurobiological substrates of human neuroticism. Cross-scale correlation analysis may provide such information. In this study, voxel-wise neuroimaging-neuroticism correlation analyses consistently showed a positive correlation between neuroticism and functional connectivity density (FCD) in the ventral striatum in 274 young Chinese adults. Partial least squares regression analysis showed that the FCD-neuroticism correlation map was significantly spatially correlated with gene expression profiles in each of six donated human brains. Neuroticism-related genes derived from the six donors consistently showed significant enrichment in the chemical synaptic transmission, circadian entrainment, long-term potentiation, inflammatory mediator regulation of transient receptor potential channels, and amphetamine addiction pathways. The protein-protein interaction analysis revealed four hub genes involved in the above pathways, including G protein subunit gamma 10, 5-hydroxytryptamine receptor 2C, prodynorphin, and calcium/calmodulin-dependent protein kinase II alpha. By combining multiscale correlation analyses and functional annotations, this study advances our understanding of the genetic and neural substrates of human neuroticism and emphasizes the importance of striatal functional properties in human neuroticism. |
| WOS关键词 | PARTIAL LEAST-SQUARES ; SEROTONIN 5-HT2C RECEPTORS ; FUNCTIONAL CONNECTIVITY ; BRAIN ; EXPRESSION ; ANXIETY ; MRI ; EXTROVERSION ; MECHANISMS ; NETWORKS |
| 资助项目 | National Key Research and Development Program of China[2018YFC1314300] ; National Natural Science Foundation of China[81425013] ; National Natural Science Foundation of China[81501451] ; Natural Science Foundation of Tianjin[18JCQNJC10900] ; Natural Science Foundation of Tianjin[17JCZDJC36300] ; Research Fund for Young Scholars of Tianjin Medical University General Hospital[ZYYFY2018007] ; Tianjin Key Technology RD Program[17ZXMFSY00090] |
| WOS研究方向 | Neurosciences & Neurology ; Radiology, Nuclear Medicine & Medical Imaging |
| 语种 | 英语 |
| 出版者 | WILEY |
| WOS记录号 | WOS:000560447600001 |
| 资助机构 | National Key Research and Development Program of China ; National Natural Science Foundation of China ; Natural Science Foundation of Tianjin ; Research Fund for Young Scholars of Tianjin Medical University General Hospital ; Tianjin Key Technology RD Program |
| 源URL | [http://ir.ia.ac.cn/handle/173211/40422]  |
| 专题 | 自动化研究所_脑网络组研究中心 |
| 通讯作者 | Yu, Chunshui |
| 作者单位 | 1.Chinese Acad Sci, CAS Ctr Excellence Brain Sci & Intelligence Techn, Shanghai, Peoples R China 2.Tianjin Med Univ, Dept Radiol, Gen Hosp, Tianjin 300052, Peoples R China 3.Tianjin Med Univ, Tianjin Key Lab Funct Imaging, Gen Hosp, Tianjin 300052, Peoples R China 4.Chinese Acad Sci, Brainnetome Ctr, Inst Automat, Beijing, Peoples R China |
| 推荐引用方式 GB/T 7714 | Xu, Qiang,Liu, Feng,Qin, Wen,et al. Multiscale neurobiological correlates of human neuroticism[J]. HUMAN BRAIN MAPPING,2020:14. |
| APA | Xu, Qiang,Liu, Feng,Qin, Wen,Jiang, Tianzi,&Yu, Chunshui.(2020).Multiscale neurobiological correlates of human neuroticism.HUMAN BRAIN MAPPING,14. |
| MLA | Xu, Qiang,et al."Multiscale neurobiological correlates of human neuroticism".HUMAN BRAIN MAPPING (2020):14. |
入库方式： OAI收割
来源：自动化研究所
浏览0
下载0
收藏0
其他版本
除非特别说明，本系统中所有内容都受版权保护，并保留所有权利。