Altered amygdala-based functional connectivity in individuals with attenuated psychosis syndrome and first-episode schizophrenia
文献类型：期刊论文
| 作者 | Kim, Woo-Sung2; Shen, Guangfan2; Liu, Congcong2; Kang, Nam-In7; Lee, Keon-Hak7; Sui, Jing3,4,5 ; Chung, Young-Chul1,2,6
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| 刊名 | SCIENTIFIC REPORTS
 |
| 出版日期 | 2020-10-19 |
| 卷号 | 10期号:1页码:9 |
| ISSN号 | 2045-2322 |
| DOI | 10.1038/s41598-020-74771-w |
| 通讯作者 | Chung, Young-Chul(chungyc@jbnu.ac.kr) |
| 英文摘要 | Altered resting-state functional connectivity (FC) of the amygdala (AMY) has been demonstrated to be implicated in schizophrenia (SZ) and attenuated psychosis syndrome (APS). Specifically, no prior work has investigated FC in individuals with APS using subregions of the AMY as seed regions of interest. The present study examined AMY subregion-based FC in individuals with APS and first-episode schizophrenia (FES) and healthy controls (HCs). The resting state FC maps of the three AMY subregions were computed and compared across the three groups. Correlation analysis was also performed to examine the relationship between the Z-values of regions showing significant group differences and symptom rating scores. Individuals with APS showed hyperconnectivity between the right centromedial AMY (CMA) and left frontal pole cortex (FPC) and between the laterobasal AMY and brain stem and right inferior lateral occipital cortex compared to HCs. Patients with FES showed hyperconnectivity between the right superficial AMY and left occipital pole cortex and between the left CMA and left thalamus compared to the APS and HCs respectively. A negative relationship was observed between the connectivity strength of the CMA with the FPC and negative-others score of the Brief Core Schema Scales in the APS group. We observed different altered FC with subregions of the AMY in individuals with APS and FES compared to HCs. These results shed light on the pathogenetic mechanisms underpinning the development of APS and SZ. |
| WOS关键词 | INTRINSIC BRAIN ACTIVITY ; PREFRONTAL CORTEX ; STATE ; RISK ; DYSCONNECTIVITY ; COORDINATION ; RELIABILITY ; ACTIVATION ; ADOLESCENT ; INTERVIEW |
| 资助项目 | Korean Mental Health Technology R&D Project, Ministry of Health & Welfare, Republic of Korea[HL19C0015] ; Korea Health Technology R&D Project through the Korea Health Industry Development Institute (KHIDI) - Ministry of Health & Welfare, Republic of Korea[HI18C2383] |
| WOS研究方向 | Science & Technology - Other Topics |
| 语种 | 英语 |
| WOS记录号 | WOS:000585197800041 |
| 出版者 | NATURE RESEARCH |
| 资助机构 | Korean Mental Health Technology R&D Project, Ministry of Health & Welfare, Republic of Korea ; Korea Health Technology R&D Project through the Korea Health Industry Development Institute (KHIDI) - Ministry of Health & Welfare, Republic of Korea |
| 源URL | [http://ir.ia.ac.cn/handle/173211/41667]  |
| 专题 | 自动化研究所_脑网络组研究中心 |
| 通讯作者 | Chung, Young-Chul |
| 作者单位 | 1.Jeonbuk Natl Univ Hosp, Dept Psychiat, Jeonju, South Korea 2.Jeonbuk Natl Univ, Med Sch, Dept Psychiat, Geonjiro 20, Jeonju, South Korea 3.Chinese Acad Sci, Brainnetome Ctr, Beijing 100190, Peoples R China 4.Chinese Acad Sci, Natl Lab Pattern Recognit, Inst Automat, Beijing 100190, Peoples R China 5.Chinese Acad Sci, Univ Chinese Acad Sci, CAS Ctr Excellence Brain Sci & Intelligence Techn, Beijing 100049, Peoples R China 6.Jeonbuk Natl Univ, Res Inst Clin Med, Biomed Res Inst, Jeonbuk Natl Univ Hosp, Jeonju, South Korea 7.Maeumsarang Hosp, Dept Psychiat, Wonju, Jeollabuk Do, South Korea |
| 推荐引用方式 GB/T 7714 | Kim, Woo-Sung,Shen, Guangfan,Liu, Congcong,et al. Altered amygdala-based functional connectivity in individuals with attenuated psychosis syndrome and first-episode schizophrenia[J]. SCIENTIFIC REPORTS,2020,10(1):9. |
| APA | Kim, Woo-Sung.,Shen, Guangfan.,Liu, Congcong.,Kang, Nam-In.,Lee, Keon-Hak.,...&Chung, Young-Chul.(2020).Altered amygdala-based functional connectivity in individuals with attenuated psychosis syndrome and first-episode schizophrenia.SCIENTIFIC REPORTS,10(1),9. |
| MLA | Kim, Woo-Sung,et al."Altered amygdala-based functional connectivity in individuals with attenuated psychosis syndrome and first-episode schizophrenia".SCIENTIFIC REPORTS 10.1(2020):9. |
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