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Association between functional and structural connectivity of the corticostriatal network in people with schizophrenia and unaffected first-degree relatives

文献类型：期刊论文

作者Li, Peng9,10; Jing, Ri-Xing7,8; Zhao, Rong-Jiang6; Shi, Le9,10; Sun, Hong-Qiang9,10; Ding, Zengbo4,5; Lin, Xiao2,3,9,10; Lu, Lin2,3,9,10; Fan, Yong1
刊名JOURNAL OF PSYCHIATRY & NEUROSCIENCE
出版日期2020-11-01
卷号45期号:6页码:395-405
ISSN号1180-4882
DOI10.1503/jpn.190015
通讯作者Lu, Lin(linlu@bjmu.edu.cn) ; Fan, Yong(yong.fan@ieee.org)
英文摘要Background Dysfunction of the corticostriatal network has been implicated in the pathophysiology of schizophrenia, but findings are inconsistent within and across imaging modalities. We used multimodal neuroimaging to analyze functional and structural connectivity in the corticostriatal network in people with schizophrenia and unaffected first-degree relatives. Methods We collected resting-state functional magnetic resonance imaging and diffusion tensor imaging scans from people with schizophrenia (n = 47), relatives (n = 30) and controls (n = 49). We compared seed-based functional and structural connectivity across groups within striatal subdivisions defined a priori. Results Compared with controls, people with schizophrenia had altered connectivity between the subdivisions and brain regions in the frontal and temporal cortices and thalamus; relatives showed different connectivity between the subdivisions and the right anterior cingulate cortex (ACC) and the left precuneus. Post-hoc t tests revealed that people with schizophrenia had decreased functional connectivity in the ventral loop (ventral striatum-right ACC) and dorsal loop (executive striatum-right ACC and sensorimotor striatum-right ACC), accompanied by decreased structural connectivity; relatives had reduced functional connectivity in the ventral loop and the dorsal loop (right executive striatum-right ACC) and no significant difference in structural connectivity compared with the other groups. Functional connectivity among people with schizophrenia in the bilateral ventral striatum-right ACC was correlated with positive symptom severity. Limitations The number of relatives included was moderate. Striatal subdivisions were defined based on a relatively low threshold, and structural connectivity was measured based on fractional anisotropy alone. Conclusion Our findings provide insight into the role of hypoconnectivity of the ventral corticostriatal system in people with schizophrenia.
WOS关键词SUBSTANTIA-NIGRA HYPERACTIVITY ; VENTRAL STRIATAL ACTIVATION ; BASAL GANGLIA ; ANTIPSYCHOTIC TREATMENT ; DIFFUSION TRACTOGRAPHY ; COGNITIVE DEFICITS ; NEGATIVE SYMPTOMS ; 1ST-EPISODE ; STATE ; PSYCHOSIS
资助项目National Basic Research Program of China[2015CB856400] ; National Natural Science Foundation of China[81501158] ; NIH[EB022573]
WOS研究方向Neurosciences & Neurology ; Psychiatry
语种英语
WOS记录号WOS:000588147000004
出版者CMA-CANADIAN MEDICAL ASSOC
资助机构National Basic Research Program of China ; National Natural Science Foundation of China ; NIH
源URL[http://ir.ia.ac.cn/handle/173211/41768]  
专题自动化研究所_个人空间
通讯作者Lu, Lin; Fan, Yong
作者单位1.Univ Penn, Perelman Sch Med, Dept Radiol, Philadelphia, PA 19104 USA
2.Peking Univ, PKU IDG McGovern Inst Brain Res, Beijing, Peoples R China
3.Peking Univ, Peking Tsinghua Ctr Life Sci, Beijing, Peoples R China
4.Peking Univ, Beijing Key Lab Drug Dependence, Beijing, Peoples R China
5.Peking Univ, Natl Inst Drug Dependence, Beijing, Peoples R China
6.Peking Univ, Dept Alcohol & Drug Dependence, Beijing Hui Long Guan Hosp, Beijing, Peoples R China
7.Univ Chinese Acad Sci, Beijing, Peoples R China
8.Chinese Acad Sci, Inst Automat, Natl Lab Pattern Recognit, Beijing, Peoples R China
9.Peking Univ, Hosp 6, Natl Clin Res Ctr Mental Disorders, Beijing, Peoples R China
10.Peking Univ, Hosp 6, Inst Mental Hlth, NHC Key Lab Mental Hlth, Beijing, Peoples R China
推荐引用方式
GB/T 7714		 Li, Peng,Jing, Ri-Xing,Zhao, Rong-Jiang,et al. Association between functional and structural connectivity of the corticostriatal network in people with schizophrenia and unaffected first-degree relatives[J]. JOURNAL OF PSYCHIATRY & NEUROSCIENCE,2020,45(6):395-405.
APA Li, Peng.,Jing, Ri-Xing.,Zhao, Rong-Jiang.,Shi, Le.,Sun, Hong-Qiang.,...&Fan, Yong.(2020).Association between functional and structural connectivity of the corticostriatal network in people with schizophrenia and unaffected first-degree relatives.JOURNAL OF PSYCHIATRY & NEUROSCIENCE,45(6),395-405.
MLA Li, Peng,et al."Association between functional and structural connectivity of the corticostriatal network in people with schizophrenia and unaffected first-degree relatives".JOURNAL OF PSYCHIATRY & NEUROSCIENCE 45.6(2020):395-405.

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