Associations between Exposure to Persistent Organic Pollutants and Thyroid Function in a Case-Control Study of East China
文献类型：期刊论文
| 作者 | Han, Xu1; Meng, Lingling2; Li, Yingming; Li, An; Turyk, Mary E.; Yang, Ruiqiang; Wang, Pu; Xiao, Ke ; Li, Wenjuan; Zhao, Junpeng1
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| 刊名 | ENVIRONMENTAL SCIENCE & TECHNOLOGY
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| 出版日期 | 2019-08-20 |
| 卷号 | 53期号:16页码:9866-9875 |
| ISSN号 | 0013-936X |
| 英文摘要 | Animal studies have indicated that persistent organic pollutants (POPs) affect thyroid hormone homeostasis, while epidemiological studies involving human have not shown consistent results. In this study, we investigated the associations between POP exposure and thyroid function among adult population of East China. One hundred eighty-six participants diagnosed with thyroid disease and 186 participants without thyroid disease from Shandong, China were enrolled in the case-control study during 2016 to 2017. We found that POP exposure was significantly and positively associated with the risk of thyroid disease. The association of thyroid disease with a sum of 17 POPs followed a nonmonotonic dose response, with an adjusted odds ratio of 2.09 (95% confidence intervals: 1.13-3.87, p = 0.019) for the second quartile. Among 186 participants in the control group, concentrations of POPs showed negative associations with triiodothyronine (T3), free T3 (FT3), thyroxine (T4), and free T4 (FT4) in males and positive associations with T4 and FT4 in females. Taken together, these findings suggest that POP exposure can disrupt thyroid hormone homeostasis and increase the risk of thyroid disease. |
| 源URL | [http://ir.rcees.ac.cn/handle/311016/42511]  |
| 专题 | 生态环境研究中心_环境化学与生态毒理学国家重点实验室 |
| 作者单位 | 1.Chinese Acad Sci, Res Ctr Ecoenvironm Sci, State Key Lab Environm Chem & Ecotoxicol, Beijing 100085, Peoples R China 2.Univ Chinese Acad Sci, Beijing 100049, Peoples R China 3.Shandong First Med Univ, Shandong Prov Qianfoshan Hosp, Hosp 1, Jinan 250014, Shandong, Peoples R China 4.Li, An; Turyk, Mary E.] Univ Illinois, Sch Publ Hlth, Chicago, IL 60612 USA |
| 推荐引用方式 GB/T 7714 | Han, Xu,Meng, Lingling,Li, Yingming,et al. Associations between Exposure to Persistent Organic Pollutants and Thyroid Function in a Case-Control Study of East China[J]. ENVIRONMENTAL SCIENCE & TECHNOLOGY,2019,53(16):9866-9875. |
| APA | Han, Xu.,Meng, Lingling.,Li, Yingming.,Li, An.,Turyk, Mary E..,...&Jiang, Guibin.(2019).Associations between Exposure to Persistent Organic Pollutants and Thyroid Function in a Case-Control Study of East China.ENVIRONMENTAL SCIENCE & TECHNOLOGY,53(16),9866-9875. |
| MLA | Han, Xu,et al."Associations between Exposure to Persistent Organic Pollutants and Thyroid Function in a Case-Control Study of East China".ENVIRONMENTAL SCIENCE & TECHNOLOGY 53.16(2019):9866-9875. |
入库方式： OAI收割
来源：生态环境研究中心
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