Black Phosphorus-Based Multimodal Nanoagent: Showing Targeted Combinatory Therapeutics against Cancer Metastasis
文献类型：期刊论文
| 作者 | Wang, Shunhao1; Shao, Jundong; Li, Zhibin; Ren, Quanzhong1; Yu, Xue-Feng; Liu, Sijin1 |
| 刊名 | NANO LETTERS
 |
| 出版日期 | 2019-08-01 |
| 卷号 | 19期号:8页码:5587-5594 |
| ISSN号 | 1530-6984 |
| 关键词 | Black phosphorus BP/DTX@PLGA selective targeting cell death lung metastasis |
| 英文摘要 | In breast cancer chemophotothermal therapy, it is a great challenge for the development of multifunctional nanoagents for precision targeting and the effective treatment of tumors, especially for metastasis. Herein, we successfully design and synthesize a multifunctional black phosphorus (BP)-based nanoagent, BP/DTX@PLGA, to address this challenge. In this composite nanoagent, BP quantum dots (BPQDs) are loaded into poly(lactic-co-glycolic acid) (PLGA) with additional conjugation of a chemotherapeutic agent, docetaxel (DTX). The in vivo distribution results demonstrate that BP/DTX@PLGA shows striking tropism for targeting both primary tumors and lung metastatic tumors. Moreover, BP/DTX@PLGA exhibits outstanding controllable chemophotothermal combinatory therapeutics, which dramatically improves the efficacy of photothermal tumor ablation when combined with near-light irradiation. Mechanistically, accelerated DTX release from the nanocomplex upon heating and thermal treatment per se synergistically incurs apoptosis-dependent cell death, resulting in the elimination of lung metastasis. Meanwhile, in vitro and in vivo results further confirm that BP/DTX@PLGA possesses good biocompatibility. This study provides a promising BP-based multimodal nanoagent to constrain cancer metastasis. |
| 源URL | [http://ir.rcees.ac.cn/handle/311016/42515]  |
| 专题 | 生态环境研究中心_环境化学与生态毒理学国家重点实验室 |
| 作者单位 | 1.Chinese Acad Sci, Res Ctr Ecoenvironm Sci, State Key Lab Environm Chem & Ecotoxicol, Beijing 100085, Peoples R China 2.Univ Chinese Acad Sci, Beijing 100049, Peoples R China 3.Chinese Acad Sci, Shenzhen Inst Adv Technol, Mat & Interfaces Ctr, Shenzhen 518055, Peoples R China |
| 推荐引用方式 GB/T 7714 | Wang, Shunhao,Shao, Jundong,Li, Zhibin,et al. Black Phosphorus-Based Multimodal Nanoagent: Showing Targeted Combinatory Therapeutics against Cancer Metastasis[J]. NANO LETTERS,2019,19(8):5587-5594. |
| APA | Wang, Shunhao,Shao, Jundong,Li, Zhibin,Ren, Quanzhong,Yu, Xue-Feng,&Liu, Sijin.(2019).Black Phosphorus-Based Multimodal Nanoagent: Showing Targeted Combinatory Therapeutics against Cancer Metastasis.NANO LETTERS,19(8),5587-5594. |
| MLA | Wang, Shunhao,et al."Black Phosphorus-Based Multimodal Nanoagent: Showing Targeted Combinatory Therapeutics against Cancer Metastasis".NANO LETTERS 19.8(2019):5587-5594. |
入库方式： OAI收割
来源：生态环境研究中心
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