Embryoid body-based RNA-seq analyses reveal a potential TBBPA multifaceted developmental toxicity
文献类型：期刊论文
| 作者 | Liang, Shaojun1; Zhou, Hui1; Yin, Nuoya1; Lu, Yuanping1; Faiola, Francesco1 |
| 刊名 | JOURNAL OF HAZARDOUS MATERIALS
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| 出版日期 | 2019-08-15 |
| 卷号 | 376页码:223-232 |
| 关键词 | Mouse embryonic stem cells (mESCs) Tetrabromobisphenol A (TBBPA) Embryoid bodies (EBs) Developmental toxicity |
| ISSN号 | 0304-3894 |
| 英文摘要 | The frequent detection of tetrabromobisphenol A (TBBPA) in the human body, especially in umbilical cord serum and breast milk, has raised concerns about TBBPA potential effects on embryonic development. The differentiation of embryonic stem cells (ESCs) in vitro can serve as a model for the early stages of embryonic development. In this study, we differentiated mouse ESCs via 3D aggregates called embryoid bodies in presence of environment and human relevant TBPPA concentrations for 28 days. We collected samples at different time points and analyzed TBBPA-dependent global gene expression changes by RNA-seq. Our analyses revealed a potential TBBPA multifaceted developmental toxicity with effects on the nervous and cardiac/skeletal muscle systems. Mechanistically, our findings suggest TBBPA endocrine disrupting activities in part via prolactin naling. |
| 源URL | [http://ir.rcees.ac.cn/handle/311016/42535]  |
| 专题 | 生态环境研究中心_环境化学与生态毒理学国家重点实验室 |
| 作者单位 | 1.Chinese Acad Sci, State Key Lab Environm Chem & Ecotoxicol, Res Ctr Ecoenvironm Sci, Beijing 100085, Peoples R China 2.Univ Chinese Acad Sci, Coll Resources & Environm, Beijing 100049, Peoples R China |
| 推荐引用方式 GB/T 7714 | Liang, Shaojun,Zhou, Hui,Yin, Nuoya,et al. Embryoid body-based RNA-seq analyses reveal a potential TBBPA multifaceted developmental toxicity[J]. JOURNAL OF HAZARDOUS MATERIALS,2019,376:223-232. |
| APA | Liang, Shaojun,Zhou, Hui,Yin, Nuoya,Lu, Yuanping,&Faiola, Francesco.(2019).Embryoid body-based RNA-seq analyses reveal a potential TBBPA multifaceted developmental toxicity.JOURNAL OF HAZARDOUS MATERIALS,376,223-232. |
| MLA | Liang, Shaojun,et al."Embryoid body-based RNA-seq analyses reveal a potential TBBPA multifaceted developmental toxicity".JOURNAL OF HAZARDOUS MATERIALS 376(2019):223-232. |
入库方式： OAI收割
来源：生态环境研究中心
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