Liquid chromatography- mass spectrometry for analysis of DNA damages induced by environmental exposure
文献类型：期刊论文
| 作者 | Yin, Junfa2 ; Zhang, Ning; Wang, Hailin2
|
| 刊名 | TRAC-TRENDS IN ANALYTICAL CHEMISTRY
 |
| 出版日期 | 2019-11-01 |
| 卷号 | 120页码:- |
| 关键词 | DNA damage DNA modification Liquid chromatography-mass spectrometry Environmental exposure Environmental health |
| ISSN号 | 0165-9936 |
| 英文摘要 | Long-term exposures to environmental toxicants are causative factors for human health effects. DNA damages are of great interest in that they can serve as the potential biomarkers of environmental exposure and mutations. Qualitative and quantitative detection of their level in genomic DNA, are helpful for the understanding of the generation, transformation, repair and fate of DNA damages and for elucidating the mechanism underlying carcinogenesis. Methodologies based on liquid chromatography-mass spectrometry (LC-MS) have shown unique advantages in accurate and highly sensitive analysis of these structurally modified DNA damages. The present review summarizes our current knowledge on LC-MS analysis of genetic DNA damages, with special emphasis on structurally chemical DNA modifications induced by environmental exposure. Advances in LC-MS analysis and monitoring of oxidative DNA lesion, DNA adducts induced by heavy metals, persistent organic pollutants, bisphenols, fine particulate matters, aldehydes and halobenzoquinones are comprehensively summarized. (c) 2019 Elsevier B.V. All rights reserved. |
| 源URL | [http://ir.rcees.ac.cn/handle/311016/42556]  |
| 专题 | 生态环境研究中心_环境化学与生态毒理学国家重点实验室 |
| 作者单位 | 1.Univ Chinese Acad Sci, Beijing 100049, Peoples R China 2.Chinese Acad Sci, Res Ctr Ecoenvironm Sci, State Key Lab Environm Chem & Ecotoxicol, Beijing 100085, Peoples R China |
| 推荐引用方式 GB/T 7714 | Yin, Junfa,Zhang, Ning,Wang, Hailin. Liquid chromatography- mass spectrometry for analysis of DNA damages induced by environmental exposure[J]. TRAC-TRENDS IN ANALYTICAL CHEMISTRY,2019,120:-. |
| APA | Yin, Junfa,Zhang, Ning,&Wang, Hailin.(2019).Liquid chromatography- mass spectrometry for analysis of DNA damages induced by environmental exposure.TRAC-TRENDS IN ANALYTICAL CHEMISTRY,120,-. |
| MLA | Yin, Junfa,et al."Liquid chromatography- mass spectrometry for analysis of DNA damages induced by environmental exposure".TRAC-TRENDS IN ANALYTICAL CHEMISTRY 120(2019):-. |
入库方式： OAI收割
来源：生态环境研究中心
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