Mass Spectrometry-Based Metabolomics Reveals Occupational Exposure to Per- and Polyfluoroalkyl Substances Relates to Oxidative Stress, Fatty Acid beta-Oxidation Disorder, and Kidney Injury in a Manufactory in China
文献类型：期刊论文
| 作者 | Lu, Yao2; Gao, Ke2; Li, Xiaona3; Tang, Zhi4; Xiang, Li3; Zhao, Hongzhi3; Fu, Jianjie2 ; Wang, Ling1; Zhu, Nali5; Cai, Zongwei3
|
| 刊名 | ENVIRONMENTAL SCIENCE & TECHNOLOGY
 |
| 出版日期 | 2019-08-20 |
| 卷号 | 53期号:16页码:9800-9809 |
| ISSN号 | 0013-936X |
| 英文摘要 | Occupational workers are usually exposed to high levels of per- and polyfluoroalkyl substances (PFASs), placing them under greater health risks compared to the general population. Herein, 40 occupational workers from a factory in China and 52 control subjects from the general population were involved in an investigation on the potential health concerns of occupational exposure to PFASs by mass spectrometry-based metabolomics analysis. The PFAS levels in plasma from both groups were analyzed. Six PFAS congeners (Sigma(6)PFASs) were found to be the main components of the 13 detected PFASs, with a geometric mean of 1770 and 22.2 ng mL(-1) in occupational workers and the general population, respectively. Metabolic profiles of the plasma samples were acquired using liquid chromatography coupled with orbitrap high-resolution mass spectrometry and gas chromatography mass spectrometry. The partial least-squares-discriminant analysis model indicated that the plasma metabolic profiles of the two groups could be clearly separated. Differential and correlation analyses were applied to discover potential biomarkers. A total of 14 potential biomarkers were identified, and they were found to be associated with oxidative stress, fatty acid beta-oxidation disorder, and kidney injury. The obtained results indicated that the health effects of occupational exposure to PFASs on workers should not be ignored. |
| 源URL | [http://ir.rcees.ac.cn/handle/311016/42560]  |
| 专题 | 生态环境研究中心_环境化学与生态毒理学国家重点实验室 |
| 作者单位 | 1.Shenzhen Ctr Dis Control & Prevent, Shenzhen 518055, Peoples R China 2.Chinese Acad Sci, Res Ctr Ecoenvironm Sci, State Key Lab Environm Chem & Ecotoxicol, Beijing 100085, Peoples R China 3.Univ Chinese Acad Sci, Coll Resources & Environm, Beijing 100049, Peoples R China 4.Hong Kong Baptist Univ, Dept Chem, State Key Lab Environm & Biol Anal, Hong Kong, Peoples R China 5.Jianghan Univ, Inst Environm & Hlth, Wuhan 430056, Hubei, Peoples R China 6.Chinese Acad Sci, Inst Biophys, Lab Prote, Beijing 100101, Peoples R China |
| 推荐引用方式 GB/T 7714 | Lu, Yao,Gao, Ke,Li, Xiaona,et al. Mass Spectrometry-Based Metabolomics Reveals Occupational Exposure to Per- and Polyfluoroalkyl Substances Relates to Oxidative Stress, Fatty Acid beta-Oxidation Disorder, and Kidney Injury in a Manufactory in China[J]. ENVIRONMENTAL SCIENCE & TECHNOLOGY,2019,53(16):9800-9809. |
| APA | Lu, Yao.,Gao, Ke.,Li, Xiaona.,Tang, Zhi.,Xiang, Li.,...&Jiang, Guibin.(2019).Mass Spectrometry-Based Metabolomics Reveals Occupational Exposure to Per- and Polyfluoroalkyl Substances Relates to Oxidative Stress, Fatty Acid beta-Oxidation Disorder, and Kidney Injury in a Manufactory in China.ENVIRONMENTAL SCIENCE & TECHNOLOGY,53(16),9800-9809. |
| MLA | Lu, Yao,et al."Mass Spectrometry-Based Metabolomics Reveals Occupational Exposure to Per- and Polyfluoroalkyl Substances Relates to Oxidative Stress, Fatty Acid beta-Oxidation Disorder, and Kidney Injury in a Manufactory in China".ENVIRONMENTAL SCIENCE & TECHNOLOGY 53.16(2019):9800-9809. |
入库方式： OAI收割
来源：生态环境研究中心
浏览0
下载0
收藏0
其他版本
除非特别说明，本系统中所有内容都受版权保护，并保留所有权利。