Metagenomic characterization of antibiotic resistance genes in Antarctic soils
文献类型：期刊论文
| 作者 | Yuan, Ke; Yu, Ke5; Yang, Ruiqiang1; Zhang, Qinghua1; Yang, Ying; Chen, Enzhong6; Lin, Lan6; Luan, Tiangang3; Chen, Wen2; Chen, Baowei |
| 刊名 | ECOTOXICOLOGY AND ENVIRONMENTAL SAFETY
 |
| 出版日期 | 2019-07-30 |
| 卷号 | 176页码:300-308 |
| 关键词 | Antibiotic resistance genes (ARGs) Metagenome Antarctica Soils Resistance level |
| ISSN号 | 0147-6513 |
| 英文摘要 | Antibiotic resistance genes (ARGs) are considered environmental pollutants. Comprehensive characterization of the ARGs in pristine environments is essential towards understanding the evolution of antibiotic resistance. Here, we analyzed ARGs in soil samples collected from relatively pristine Antarctica using metagenomic approaches. We identified 79 subtypes related to 12 antibiotic classes in Antarctic soils, in which ARGs related to multidrug and polypeptide were dominant. The characteristics of ARGs in Antarctic soils were significantly different from those in active sludge, chicken feces and swine feces, in terms of composition, abundance and potential transferability. ARG subtypes (e.g., bacA, ceoB, dfrE, mdtB, amrB, and acrB) were more abundant than others in Antarctic soils. Approximately 60% of the ARGs conferred antibiotic resistance via an efflux mechanism, and a low fraction of ARGs (similar to 16%) might be present on plasmids. Culturable bacterial consortiums isolated from Antarctic soils were consistently susceptible to most of the tested antibiotics frequently used in clinical therapies. The amrB and ceoB carried by culturable species did not express the resistance to aminoglycoside and fluoroquinolone at the levels of clinical concern. Our results suggest that the wide use of antibiotics may have contributed to developing higher antibiotic resistance and mobility. |
| 源URL | [http://ir.rcees.ac.cn/handle/311016/42562]  |
| 专题 | 生态环境研究中心_环境化学与生态毒理学国家重点实验室 |
| 作者单位 | 1.Southern Med Univ, Zhujiang Hosp, Guangzhou 510282, Guangdong, Peoples R China 2.Sun Yat Sen Univ, Sch Environm Sci & Engn, Guangzhou 510275, Guangdong, Peoples R China 3.Chinese Acad Sci, Res Ctr Ecoenvironm Sci, State Key Lab Environm Chem & Ecotoxicol, Beijing 100085, Peoples R China 4.Sun Yat Sen Univ, Sch Publ Hlth, Guangzhou 510275, Guangdong, Peoples R China 5.Sun Yat Sen Univ, Guangdong Prov Key Lab Marine Resources & Coastal, Sch Marine Sci, Guangzhou 510275, Guangdong, Peoples R China 6.Peking Univ, Sch Environm & Energy, Shenzhen Grad Sch, Shenzhen 518055, Guangdong, Peoples R China |
| 推荐引用方式 GB/T 7714 | Yuan, Ke,Yu, Ke,Yang, Ruiqiang,et al. Metagenomic characterization of antibiotic resistance genes in Antarctic soils[J]. ECOTOXICOLOGY AND ENVIRONMENTAL SAFETY,2019,176:300-308. |
| APA | Yuan, Ke.,Yu, Ke.,Yang, Ruiqiang.,Zhang, Qinghua.,Yang, Ying.,...&Chen, Baowei.(2019).Metagenomic characterization of antibiotic resistance genes in Antarctic soils.ECOTOXICOLOGY AND ENVIRONMENTAL SAFETY,176,300-308. |
| MLA | Yuan, Ke,et al."Metagenomic characterization of antibiotic resistance genes in Antarctic soils".ECOTOXICOLOGY AND ENVIRONMENTAL SAFETY 176(2019):300-308. |
入库方式： OAI收割
来源：生态环境研究中心
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