5-fluorouracil-induced neurotoxicity in rat cerebellum granule cells involves oxidative stress and activation of caspase-3 pathway
文献类型：期刊论文
| 作者 | Zhang, Yang; Yin, Nuoya; Liang, Shengxian; Shen, Su; Li, Dandan; Faiola, Francesco |
| 刊名 | INTERNATIONAL JOURNAL OF CLINICAL AND EXPERIMENTAL MEDICINE
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| 出版日期 | 2019-01 |
| 卷号 | 12期号:3页码:2334-2343 |
| 关键词 | 5-fluorouracil neurotoxicity cerebellum granule cells oxidative stress caspase |
| ISSN号 | 1940-5901 |
| 英文摘要 | 5-Fluorouracil (5-FU) is a widely used anticancer drug that acts by blocking DNA replication. Although the side effects of 5-FU are well documented, the mechanism of 5-FU-induced neurotoxicity remains unclear. The current study was performed to investigate the toxicity of 5-FU to rat cerebellum granule cells (CGCs) and to elucidate the corresponding molecular mechanisms. We demonstrated that 5-FU exhibited significant cellular toxicity to CGCs, in a dose-dependent manner, and that it altered intracellular Ca2+ levels. The accumulation of intracellular reactive oxygen species in CGCs revealed that 5-FU also induced oxidative stress. Moreover, 5-FU-treated cells showed elevated caspase-3 activity. Furthermore, intraperitoneally administered 5-FU caused slight degenerative changes in the rat cerebellum granular layer. Taken together, these findings revealed that 5-FU substantially impaired the survival of CGCs by inducing oxidative stress and activating the caspase-3 apoptotic pathway. |
| 源URL | [http://ir.rcees.ac.cn/handle/311016/42883]  |
| 专题 | 生态环境研究中心_环境化学与生态毒理学国家重点实验室 |
| 作者单位 | 1.Univ Chinese Acad Sci, Coll Resources & Environm, Beijing 100049, Peoples R China 2.Capital Med Univ, Beijing Friendship Hosp, Dept Pharm, Beijing 100050, Peoples R China 3.Chinese Acad Sci, Res Ctr Ecoenvironm Sci, State Key Lab Environm Chem & Ecotoxicol, 18 Shuangqing Rd, Beijing 100085, Peoples R China |
| 推荐引用方式 GB/T 7714 | Zhang, Yang,Yin, Nuoya,Liang, Shengxian,et al. 5-fluorouracil-induced neurotoxicity in rat cerebellum granule cells involves oxidative stress and activation of caspase-3 pathway[J]. INTERNATIONAL JOURNAL OF CLINICAL AND EXPERIMENTAL MEDICINE,2019,12(3):2334-2343. |
| APA | Zhang, Yang,Yin, Nuoya,Liang, Shengxian,Shen, Su,Li, Dandan,&Faiola, Francesco.(2019).5-fluorouracil-induced neurotoxicity in rat cerebellum granule cells involves oxidative stress and activation of caspase-3 pathway.INTERNATIONAL JOURNAL OF CLINICAL AND EXPERIMENTAL MEDICINE,12(3),2334-2343. |
| MLA | Zhang, Yang,et al."5-fluorouracil-induced neurotoxicity in rat cerebellum granule cells involves oxidative stress and activation of caspase-3 pathway".INTERNATIONAL JOURNAL OF CLINICAL AND EXPERIMENTAL MEDICINE 12.3(2019):2334-2343. |
入库方式： OAI收割
来源：生态环境研究中心
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