Adverse Effects of Fine-Particle Exposure on Joints and Their Surrounding Cells and Microenvironment
文献类型：期刊论文
| 作者 | Zhang, Shuping ; Ren, Quanzhong; Qi, Hui; Liu, Sijin; Liu, Yajun
|
| 刊名 | ACS NANO
 |
| 出版日期 | 2019-03 |
| 卷号 | 13期号:3页码:2729-2748 |
| 关键词 | fine particles engineered nanomaterials joints surrounding cells arthritis direct toxicity indirect toxicity systemic inflammation |
| ISSN号 | 1936-0851 |
| 英文摘要 | Current understanding of the health risks and adverse effects upon exposure to fine particles is premised on the direct association of particles with target organs, particularly the lung; however, fine-particle exposure has also been found to have detrimental effects on sealed cavities distant to the portal-of-entry, such as joints. Moreover, the fundamental toxicological issues have been ascribed to the direct toxic mechanisms, in particular, oxidative stress and proinflammatory responses, without exploring the indirect mechanisms, such as compensated, adaptive, and secondary effects. In this Review, we recapitulate the current findings regarding the detrimental effects of fine-particle exposure on joints, the surrounding cells, and microenvironment, as well as their deteriorating impact on the progression of arthritis. We also elaborate the likely molecular mechanisms underlying the particle-induced detrimental influence on joints, not limited to direct toxicity, but also considering the other indirect mechanisms. Because of the similarities between fine air particles and engineered nanomaterials, we compare the toxicities of engineered nanomaterials to those of fine air particles. Arthritis and joint injuries are prevalent, particularly in the elderly population. Considering the severity of global exposure to fine particles and limited studies assessing the detrimental effects of fine particle exposure on joints and arthritis, this Review aims to appeal to a broad interest and to promote more research efforts in this field. |
| 源URL | [http://ir.rcees.ac.cn/handle/311016/42892]  |
| 专题 | 生态环境研究中心_环境化学与生态毒理学国家重点实验室 |
| 作者单位 | 1.Beijing Res Inst Traumatol & Orthopaed, Beijing 100035, Peoples R China 2.MIT, Inst Med Engn & Sci, 77 Massachusetts Ave, Cambridge, MA 02139 USA 3.Chinese Acad Sci, Res Ctr Ecoenvironm Sci, State Key Lab Environm Chem & Ecotoxicol, Beijing 100085, Peoples R China 4.Peking Univ, Beijing Jishuitan Hosp, Hlth Sci Ctr, Beijing 100035, Peoples R China |
| 推荐引用方式 GB/T 7714 | Zhang, Shuping,Ren, Quanzhong,Qi, Hui,et al. Adverse Effects of Fine-Particle Exposure on Joints and Their Surrounding Cells and Microenvironment[J]. ACS NANO,2019,13(3):2729-2748. |
| APA | Zhang, Shuping,Ren, Quanzhong,Qi, Hui,Liu, Sijin,&Liu, Yajun.(2019).Adverse Effects of Fine-Particle Exposure on Joints and Their Surrounding Cells and Microenvironment.ACS NANO,13(3),2729-2748. |
| MLA | Zhang, Shuping,et al."Adverse Effects of Fine-Particle Exposure on Joints and Their Surrounding Cells and Microenvironment".ACS NANO 13.3(2019):2729-2748. |
入库方式： OAI收割
来源：生态环境研究中心
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