Desferrioxamine-caffeine shows improved efficacy in chelating iron and depleting cancer stem cells
文献类型：期刊论文
| 作者 | Li, Bin; Esposito, Breno Pannia; Wang, Shunhao; Zhang, Jie; Xu, Ming; Zhang, Shuping ; Zhang, Zhihong; Liu, Sijin
|
| 刊名 | JOURNAL OF TRACE ELEMENTS IN MEDICINE AND BIOLOGY
 |
| 出版日期 | 2019-01 |
| 卷号 | 52页码:232-238 |
| 关键词 | Iron chelation DFCAF CSCs EMT Cancer therapeutics |
| ISSN号 | 0946-672X |
| 英文摘要 | Iron chelation has already been proposed to be a feasible strategy for cancer therapeutics in that reinforced iron demand is demonstrated in cancer cells, and quite a few iron chelators have been developed for this purpose. Desferrioxamine (DFO), an iron chelator approved by the U.S. Food and Drug Administration (FDA), has been extensively examined to remove extra iron. However, DFO has been found to harbor limited efficacies in combating cancer cells due to poor cellular permeability. In the current study, we synthesized the DFO derivative, named as desferrioxamine-caffeine dimer (DFCAF) by linking DFO to caffeine with high purity and excellent stability. Our data showed that DFCAF displayed greater cellular permeability to chelate intracellular iron in 4T1 breast cancer cells than DFO, posing more inhibition on cell growth and cellular motility/invasion. Importantly, DFCAF was uncovered to remarkably deplete cancer stem cells (CSCs), as characterized by the remarkable decrease of the CD44(+/high)/CD24(-/low) and ALDH(+/high) subpopulation. In parallel, DFCAF was also found to greatly reverse epithelial-mesenchymal transition (EMT), suggesting the potential application to restrain tumor progression and metastasis. Collectively, these data unveiled the improved efficacy to target cancer cells and to deplete CSCs, thus opening a new path for better cancer therapeutics through iron chelation. |
| 源URL | [http://ir.rcees.ac.cn/handle/311016/42923]  |
| 专题 | 生态环境研究中心_环境化学与生态毒理学国家重点实验室 |
| 作者单位 | 1.Univ Chinese Acad Sci, Beijing 100049, Peoples R China 2.Tianjin Med Univ, Tianjin Inst Urol, Hosp 2, Dept Urol, Tianjin 300211, Peoples R China 3.Chinese Acad Sci, Res Ctr Ecoenvironm Sci, State Key Lab Environm Chem & Ecotoxicol, Beijing 100085, Peoples R China 4.Univ Sao Paulo, Inst Chem, Dept Fundamental Chem, BR-05508000 Sao Paulo, Brazil 5.MIT, Inst Med Engn & Sci, 77 Massachusetts Ave, Cambridge, MA 02139 USA |
| 推荐引用方式 GB/T 7714 | Li, Bin,Esposito, Breno Pannia,Wang, Shunhao,et al. Desferrioxamine-caffeine shows improved efficacy in chelating iron and depleting cancer stem cells[J]. JOURNAL OF TRACE ELEMENTS IN MEDICINE AND BIOLOGY,2019,52:232-238. |
| APA | Li, Bin.,Esposito, Breno Pannia.,Wang, Shunhao.,Zhang, Jie.,Xu, Ming.,...&Liu, Sijin.(2019).Desferrioxamine-caffeine shows improved efficacy in chelating iron and depleting cancer stem cells.JOURNAL OF TRACE ELEMENTS IN MEDICINE AND BIOLOGY,52,232-238. |
| MLA | Li, Bin,et al."Desferrioxamine-caffeine shows improved efficacy in chelating iron and depleting cancer stem cells".JOURNAL OF TRACE ELEMENTS IN MEDICINE AND BIOLOGY 52(2019):232-238. |
入库方式： OAI收割
来源：生态环境研究中心
浏览0
下载0
收藏0
其他版本
除非特别说明，本系统中所有内容都受版权保护，并保留所有权利。