Design, synthesis and evaluation of lactoside-derived galectin-3 inhibitors
文献类型：期刊论文
| 作者 | He, Peng; Zhao, Chuanfang; Sun, Xue; Du, Yuguo |
| 刊名 | JOURNAL OF CARBOHYDRATE CHEMISTRY
 |
| 出版日期 | 2019-03-24 |
| 卷号 | 38期号:3页码:151-166 |
| 关键词 | Docking galectin-3 inhibitors lactosides SPR |
| ISSN号 | 0732-8303 |
| 英文摘要 | Based on docking computation, a panel of lactoside derivatives have been designed as galectin-3 inhibitors. Suitable functional group modifications at C '-3 of methyl lactoside were predicted to supply some additional pi-cation, pi horizontal ellipsis H-O, and hydrogen bond interactions between the designed substrates and galectin-3 residues. The selected compounds, giving higher TotalScore in docking calculations, were thus synthesized, and their binding affinities toward galectin-3 were evaluated with SPR assay. |
| 源URL | [http://ir.rcees.ac.cn/handle/311016/42924]  |
| 专题 | 生态环境研究中心_环境化学与生态毒理学国家重点实验室 |
| 作者单位 | 1.Chinese Acad Sci, Ecoenvironm Sci Res Ctr, State Key Lab Environm Chem & Ecotoxicol, Beijing, Peoples R China 2.Univ Chinese Acad Sci, Sch Chem Sci, Beijing, Peoples R China |
| 推荐引用方式 GB/T 7714 | He, Peng,Zhao, Chuanfang,Sun, Xue,et al. Design, synthesis and evaluation of lactoside-derived galectin-3 inhibitors[J]. JOURNAL OF CARBOHYDRATE CHEMISTRY,2019,38(3):151-166. |
| APA | He, Peng,Zhao, Chuanfang,Sun, Xue,&Du, Yuguo.(2019).Design, synthesis and evaluation of lactoside-derived galectin-3 inhibitors.JOURNAL OF CARBOHYDRATE CHEMISTRY,38(3),151-166. |
| MLA | He, Peng,et al."Design, synthesis and evaluation of lactoside-derived galectin-3 inhibitors".JOURNAL OF CARBOHYDRATE CHEMISTRY 38.3(2019):151-166. |
入库方式： OAI收割
来源：生态环境研究中心
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