Design, synthesis, and evaluation of alpha-galactopyranosylceramide mimics promoting Th2 cytokines production
文献类型：期刊论文
| 作者 | Hu, Liyan; Zhao, Chuanfang; Ma, Juan; Jing, Yang; Du, Yuguo |
| 刊名 | BIOORGANIC & MEDICINAL CHEMISTRY LETTERS
 |
| 出版日期 | 2019-06-01 |
| 卷号 | 29期号:11页码:1357-1362 |
| 关键词 | KRN7000 OCH CD1d Th2 cytokines NKT cells |
| ISSN号 | 0960-894X |
| 英文摘要 | The binding properties of CD1d/glycolipid/TCR, glycolipid/TCR interactions in particular, have been investigated using docking computation. Accordingly, efficient modification on C-6' of galactose head was recommended in this report to favor the production of Th2 cytokines. The designed glycolipids have been successfully prepared taking advantages of inverse glycosylation procedure, and their abilities to stimulate mouse iNKT cells in vivo have been tested. Compound 9, having p-hydroxyphenylpropionyl amide group on C-6', presented the best result with respect to the selectivity and quantity on Th2-type cytokine IL-4. We found that the increased glycolipid/TCR interaction might be critical in designing new substrate with Th2-biased cytokine production. |
| 源URL | [http://ir.rcees.ac.cn/handle/311016/42925]  |
| 专题 | 生态环境研究中心_环境化学与生态毒理学国家重点实验室 |
| 作者单位 | 1.Univ Chinese Acad Sci, Sch Chem Sci, Beijing 100049, Peoples R China 2.Jiangxi Normal Univ, Natl Engn Res Ctr Carbohydrate Synth, Nanchang 330022, Jiangxi, Peoples R China 3.Chinese Acad Sci, Res Ctr Ecoenvironm Sci, State Key Lab Environm Chem & Ecotoxicol, Beijing 100085, Peoples R China |
| 推荐引用方式 GB/T 7714 | Hu, Liyan,Zhao, Chuanfang,Ma, Juan,et al. Design, synthesis, and evaluation of alpha-galactopyranosylceramide mimics promoting Th2 cytokines production[J]. BIOORGANIC & MEDICINAL CHEMISTRY LETTERS,2019,29(11):1357-1362. |
| APA | Hu, Liyan,Zhao, Chuanfang,Ma, Juan,Jing, Yang,&Du, Yuguo.(2019).Design, synthesis, and evaluation of alpha-galactopyranosylceramide mimics promoting Th2 cytokines production.BIOORGANIC & MEDICINAL CHEMISTRY LETTERS,29(11),1357-1362. |
| MLA | Hu, Liyan,et al."Design, synthesis, and evaluation of alpha-galactopyranosylceramide mimics promoting Th2 cytokines production".BIOORGANIC & MEDICINAL CHEMISTRY LETTERS 29.11(2019):1357-1362. |
入库方式： OAI收割
来源：生态环境研究中心
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