Environmental and human relevant PFOS and PFOA doses alter human mesenchymal stem cell self-renewal, adipogenesis and osteogenesis
文献类型：期刊论文
| 作者 | Liu, Shuyu; Yang, Renjun; Yin, Nuoya; Wang, Yuan-Liang; Faiola, Francesco |
| 刊名 | ECOTOXICOLOGY AND ENVIRONMENTAL SAFETY
 |
| 出版日期 | 2019-03 |
| 卷号 | 169页码:564-572 |
| 关键词 | PFOS/PFOA Human mesenchymal stem cells (hMSCs) Developmental toxicity CD90 PPAR gamma Osteogenesis |
| ISSN号 | 0147-6513 |
| 英文摘要 | PFOS and PFOA are two of the most abundant perfluorinated compounds (PFCs) in the environment. Previous studies have reported they have a long half-life (up to five years) once they enter into the human body. Moreover, they can potentially promote the adipogenic process by activating PPARy. However, little is known about PFOS and PFOA chronic health impacts on humans. In this study, we employed primary human mesenchymal stem cells (hMSCs) and demonstrated that PFOS and PFOA exerted acute cytotoxicity and affected adipogenesis and osteogenesis at environmental and human relevant doses. In fact, PFOS and PFOA impaired the proper expression of CD90 (a surface antigen highly enriched in undifferentiated hMSCs) and promoted adipogenesis, presumably via their interaction with PPARy. Moreover, PFOA partly disturbed osteogenesis. Thus, our findings not only validated the health risks of PFOS and PFOA, but also revealed new potential long-term PFOS/PFOA impacts on humans. |
| 源URL | [http://ir.rcees.ac.cn/handle/311016/42942]  |
| 专题 | 生态环境研究中心_环境化学与生态毒理学国家重点实验室 |
| 作者单位 | 1.Univ Calif San Diego, Sect Mol Biol, La Jolla, CA 92093 USA 2.Fujian Med Univ, Sch Publ Hlth, Dept Prevent Med, Fuzhou 350108, Fujian, Peoples R China 3.Univ Chinese Acad Sci, Coll Resources & Environm, Beijing 100049, Peoples R China 4.Chinese Acad Sci, Res Ctr Ecoenvironm Sci, State Key Lab Environm Chem & Ecotoxicol, Beijing 100085, Peoples R China |
| 推荐引用方式 GB/T 7714 | Liu, Shuyu,Yang, Renjun,Yin, Nuoya,et al. Environmental and human relevant PFOS and PFOA doses alter human mesenchymal stem cell self-renewal, adipogenesis and osteogenesis[J]. ECOTOXICOLOGY AND ENVIRONMENTAL SAFETY,2019,169:564-572. |
| APA | Liu, Shuyu,Yang, Renjun,Yin, Nuoya,Wang, Yuan-Liang,&Faiola, Francesco.(2019).Environmental and human relevant PFOS and PFOA doses alter human mesenchymal stem cell self-renewal, adipogenesis and osteogenesis.ECOTOXICOLOGY AND ENVIRONMENTAL SAFETY,169,564-572. |
| MLA | Liu, Shuyu,et al."Environmental and human relevant PFOS and PFOA doses alter human mesenchymal stem cell self-renewal, adipogenesis and osteogenesis".ECOTOXICOLOGY AND ENVIRONMENTAL SAFETY 169(2019):564-572. |
入库方式： OAI收割
来源：生态环境研究中心
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