Exposure to ambient fine particles causes abnormal energy metabolism and ATP decrease in lung tissue
文献类型：期刊论文
| 作者 | Jin, Xiaoting; Su, Huilan; Ding, Guobin; Sun, Zhendong; Li, Zhuoyu |
| 刊名 | CHEMOSPHERE
 |
| 出版日期 | 2019-06 |
| 卷号 | 224页码:29-38 |
| 关键词 | PM2.5 ATP TCA cycle Glycolysis Metabolic rewiring |
| ISSN号 | 0045-6535 |
| 英文摘要 | Airborne fine particles, generating from human activities, have drawn increasing attention due to their potential lung health hazards. The currently available toxicological data on fine particles is still not sufficient to explain their cause-and-effect. Based on well reported critical role of ATP on maintaining lung structure and function, the alterations of ATP production and energy metabolism in lungs of rats exposed to different dosages of seasonal PM2.5 were investigated. Haze dosage PM2.5 exposure was demonstrated to reduce the ATP production. Activity of critical enzymes in TCA cycle, such as malate dehydrogenase (MDH) and citrate synthase (CS), and expression of mitochondrial respiration chain genes were attenuated in groups exposed to haze dosage PM2.5. In contrast, there was prominent augment of glycolytic markers at haze dosage PM2.5, including metabolite contents (pyruvate and lactic acid), enzyme activities (hexokinase (HK) and pyruvate kinase (PKM)), along with mRNA levels of PKM and LDH. Consequently, sub-chronic exposure to seasonal haze PM2.5 caused reduction in ATP generation and metabolic rewiring from TCA cycle to glycolysis. Our findings can help better understand the toxicological mechanism of lung disease caused by particulate air pollution. (C) 2019 Elsevier Ltd. All rights reserved. |
| 源URL | [http://ir.rcees.ac.cn/handle/311016/42946]  |
| 专题 | 生态环境研究中心_环境化学与生态毒理学国家重点实验室 |
| 作者单位 | 1.Chinese Acad Sci, Res Ctr Ecoenvironm Sci, State Key Lab Environm Chem & Ecotoxicol, Beijing 100085, Peoples R China 2.Shanxi Univ, Inst Biotechnol, Key Lab Chem Biol & Mol Engn, Natl Minist Educ, Taiyuan 030006, Shanxi, Peoples R China 3.Shanxi Univ, Inst Biomed Sci, Taiyuan 030006, Shanxi, Peoples R China 4.Shanxi Univ, Sch Life Sci, Taiyuan 030006, Shanxi, Peoples R China |
| 推荐引用方式 GB/T 7714 | Jin, Xiaoting,Su, Huilan,Ding, Guobin,et al. Exposure to ambient fine particles causes abnormal energy metabolism and ATP decrease in lung tissue[J]. CHEMOSPHERE,2019,224:29-38. |
| APA | Jin, Xiaoting,Su, Huilan,Ding, Guobin,Sun, Zhendong,&Li, Zhuoyu.(2019).Exposure to ambient fine particles causes abnormal energy metabolism and ATP decrease in lung tissue.CHEMOSPHERE,224,29-38. |
| MLA | Jin, Xiaoting,et al."Exposure to ambient fine particles causes abnormal energy metabolism and ATP decrease in lung tissue".CHEMOSPHERE 224(2019):29-38. |
入库方式： OAI收割
来源：生态环境研究中心
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