Human Pluripotent Stem Cells as Tools for Predicting Developmental Neural Toxicity of Chemicals: Strategies, Applications, and Challenges
文献类型：期刊论文
| 作者 | Liang, Shengxian; Yin, Nuoya; Faiola, Francesco |
| 刊名 | STEM CELLS AND DEVELOPMENT
 |
| 出版日期 | 2019-06-15 |
| 卷号 | 28期号:12页码:755-768 |
| 关键词 | developmental neural toxicity (DNT) human pluripotent stem cells (hPSCs) neural differentiation neurons astrocytes oligodendrocytes |
| ISSN号 | 1547-3287 |
| 英文摘要 | The human central nervous system (CNS) is very sensitive to perturbations, since it performs sophisticated biological processes and requires cooperation from multiple neural cell types. Subtle interference from exogenous chemicals, such as environmental pollutants, industrial chemicals, drug components, food additives, and cosmetic constituents, may initiate severe developmental neural toxicity (DNT). Human pluripotent stem cell (hPSC)-based neural differentiation assays provide effective and promising tools to help evaluate potential DNT caused by those toxicants. In fact, the specification of neural lineages in vitro recapitulates critical CNS developmental processes, such as patterning, differentiation, neurite outgrowth, synaptogenesis, and myelination. Hence, the established protocols to generate a repertoire of neural derivatives from hPSCs greatly benefit the in vitro evaluation of DNT. In this review, we first dissect the various differentiation protocols inducing neural cells from hPSCs, with an emphasis on the signaling pathways and endpoint markers defining each differentiation stage. We then highlight the studies with hPSC-based protocols predicting developmental neural toxicants, and discuss remaining challenges. We hope this review can provide insights for the further progress of DNT studies. |
| 源URL | [http://ir.rcees.ac.cn/handle/311016/42955]  |
| 专题 | 生态环境研究中心_环境化学与生态毒理学国家重点实验室 |
| 作者单位 | 1.Univ Chinese Acad Sci, Coll Resources & Environm, Beijing, Peoples R China 2.Chinese Acad Sci, State Key Lab Environm Chem & Ecotoxicol, Res Ctr Ecoenvironm Sci, POB 2871,18 Shuangqing Rd, Beijing 100085, Peoples R China |
| 推荐引用方式 GB/T 7714 | Liang, Shengxian,Yin, Nuoya,Faiola, Francesco. Human Pluripotent Stem Cells as Tools for Predicting Developmental Neural Toxicity of Chemicals: Strategies, Applications, and Challenges[J]. STEM CELLS AND DEVELOPMENT,2019,28(12):755-768. |
| APA | Liang, Shengxian,Yin, Nuoya,&Faiola, Francesco.(2019).Human Pluripotent Stem Cells as Tools for Predicting Developmental Neural Toxicity of Chemicals: Strategies, Applications, and Challenges.STEM CELLS AND DEVELOPMENT,28(12),755-768. |
| MLA | Liang, Shengxian,et al."Human Pluripotent Stem Cells as Tools for Predicting Developmental Neural Toxicity of Chemicals: Strategies, Applications, and Challenges".STEM CELLS AND DEVELOPMENT 28.12(2019):755-768. |
入库方式： OAI收割
来源：生态环境研究中心
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