Interventional Photothermal Therapy Enhanced Brachytherapy: A New Strategy to Fight Deep Pancreatic Cancer
文献类型：期刊论文
| 作者 | Zhang, Fengrong; Han, Xianlin; Hu, Yanyan; Wang, Shunhao; Liu, Shuang; Pan, Xueting; Wang, Hongyu; Ma, Junjie; Wang, Weiwei; Li, Shanshan |
| 刊名 | ADVANCED SCIENCE
 |
| 出版日期 | 2019-03-06 |
| 卷号 | 6期号:5页码:- |
| 关键词 | biodegradable brachytherapy honeycomb-like gold interventional photothermal therapy pancreatic cancer |
| ISSN号 | 2198-3844 |
| 英文摘要 | Photothermal-radiotherapy (PT-RT) is an effective strategy for relieving hypoxia-related radiotherapy resistance and inducing tumor-specific cell apoptosis/necrosis. Nevertheless, limited tissue penetration of near-infrared (NIR) laser and the serious side effects of high-dose radiation severely hinder its applications for deep tumors. An interventional photothermal-brachytherapy (IPT-BT) technology is proposed here for the internal site-specific treatment of deep tumors. This technology utilizes a kind of biodegradable honeycomb-like gold nanoparticles (HGNs) acting as both internal photothermal agents and radiosensitizers. A high tumor inhibition rate of 96.6% is achieved in SW1990 orthotopic pancreatic tumor-bearing mice by HGNs-mediated IPT-BT synergistic therapy. Interestingly, this approach effectively causes double-stranded DNA damage and improves the oxygen supply and the penetration of nanoparticles inside the tumor. Therefore, it is believed that this strategy may open up a new avenue for PT-RT synergistic therapy of deep malignant tumors and has a significant impact on the future clinical translation. |
| 源URL | [http://ir.rcees.ac.cn/handle/311016/42965]  |
| 专题 | 生态环境研究中心_环境化学与生态毒理学国家重点实验室 |
| 作者单位 | 1.Beijing Univ Chem Technol, Beijing Adv Innovat Ctr Soft Matter Sci & Engn, State Key Lab Organic Inorgan Composites,Bionanom, Beijing Lab Biomed Mat,Beijing Key Lab Bioproc, Beijing 100029, Peoples R China 2.Peking Union Med Coll Hosp, Dept Gen Surg, Beijing 100730, Peoples R China 3.Peoples Liberat Army Gen Hosp, Affiliated Hosp 1, Dept Med, Beijing 100048, Peoples R China 4.Gen Hosp Peoples Liberat Army, Dept Intervent Ultrasound, Beijing 100853, Peoples R China 5.Chinese Acad Sci, State Key Lab Environm Chem & Ecotoxicol, Res Ctr Ecoenvironm Sci, Beijing 100085, Peoples R China |
| 推荐引用方式 GB/T 7714 | Zhang, Fengrong,Han, Xianlin,Hu, Yanyan,et al. Interventional Photothermal Therapy Enhanced Brachytherapy: A New Strategy to Fight Deep Pancreatic Cancer[J]. ADVANCED SCIENCE,2019,6(5):-. |
| APA | Zhang, Fengrong.,Han, Xianlin.,Hu, Yanyan.,Wang, Shunhao.,Liu, Shuang.,...&Liu, Huiyu.(2019).Interventional Photothermal Therapy Enhanced Brachytherapy: A New Strategy to Fight Deep Pancreatic Cancer.ADVANCED SCIENCE,6(5),-. |
| MLA | Zhang, Fengrong,et al."Interventional Photothermal Therapy Enhanced Brachytherapy: A New Strategy to Fight Deep Pancreatic Cancer".ADVANCED SCIENCE 6.5(2019):-. |
入库方式： OAI收割
来源：生态环境研究中心
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