Molecular mechanism of endocrine-disruptive effects induced by Bisphenol A: The role of transmembrane G-protein estrogen receptor 1 and integrin alpha v beta 3
文献类型：期刊论文
| 作者 | Sheng, Zhiguo; Wang, Cong ; Ren, Furong; Liu, Yuxiang; Zhu, Benzhan
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| 刊名 | JOURNAL OF ENVIRONMENTAL SCIENCES
 |
| 出版日期 | 2019 |
| 卷号 | 75页码:1-13 |
| 关键词 | Bisphenol A Low-dose effects G protein-coupled estrogen receptor 1 Integrin alpha v beta 3 Reproductive toxicity Thyroxine interference effect |
| ISSN号 | 1001-0742 |
| 英文摘要 | Bisphenol A (BPA) is one of the highest volume industrial products worldwide and has been widely used to make various products as the intermediates of polycarbonate plastics and epoxy resins. Inevitably, general population has been widely exposed to BPA due to extensive use of BPA containing products. BPA has similar chemical structure with the natural estrogen and has been shown to induce a variety of estrogen-like endocrine effects on organism in vivo or in vitro. High doses of BPA tend to act as antagonist of estrogen receptors (ERs) by directly regulating the genomic transcription. However, BPA at environmentally relevant low-dose always disrupt the biological function via a non-genomic manner mediated by membrane receptors, rather than ERs. Although some studies had investigated the non-genomic effects of low-dose BPA, the exact molecular mechanisms till remains unclear. Recently, we found that membrane G protein-coupled estrogen receptor 1 and integrin alpha v beta 3 and its relative signal pathways participate in the induction of male germ cell proliferation and thyroid transcription disruption by the low-dose BPA. A profound understanding for the mechanism of action of the environmentally relevant BPA exposure not only contributes to objectively evaluate and predict the potential influence to human health, but also provides theoretical basis and methodological support for assessing health effects trigged by other estrogen-like environmental endocrine disruptors. Based mainly on our recent findings, this review outlines the research progress of molecular mechanism on endocrine disrupting effects of environmental low-dose BPA, existing problems and some consideration for future studies. (c) 2018 The Research Center for Eco-Environmental Sciences, Chinese Academy of Sciences. Published by Elsevier B.V. |
| 源URL | [http://ir.rcees.ac.cn/handle/311016/42978]  |
| 专题 | 生态环境研究中心_环境化学与生态毒理学国家重点实验室 |
| 作者单位 | 1.Univ Chinese Acad Sci, Beijing 100049, Peoples R China 2.Chinese Acad Sci, Res Ctr Ecoenvironm Sci, Beijing 100085, Peoples R China 3.Xinjiang Normal Univ, Coll Chem & Chem Engn, Urumqi 830054, Peoples R China |
| 推荐引用方式 GB/T 7714 | Sheng, Zhiguo,Wang, Cong,Ren, Furong,et al. Molecular mechanism of endocrine-disruptive effects induced by Bisphenol A: The role of transmembrane G-protein estrogen receptor 1 and integrin alpha v beta 3[J]. JOURNAL OF ENVIRONMENTAL SCIENCES,2019,75:1-13. |
| APA | Sheng, Zhiguo,Wang, Cong,Ren, Furong,Liu, Yuxiang,&Zhu, Benzhan.(2019).Molecular mechanism of endocrine-disruptive effects induced by Bisphenol A: The role of transmembrane G-protein estrogen receptor 1 and integrin alpha v beta 3.JOURNAL OF ENVIRONMENTAL SCIENCES,75,1-13. |
| MLA | Sheng, Zhiguo,et al."Molecular mechanism of endocrine-disruptive effects induced by Bisphenol A: The role of transmembrane G-protein estrogen receptor 1 and integrin alpha v beta 3".JOURNAL OF ENVIRONMENTAL SCIENCES 75(2019):1-13. |
入库方式： OAI收割
来源：生态环境研究中心
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