Silver nanoparticles selectively induce human oncogenic gamma-herpesvirus-related cancer cell death through reactivating viral lytic replication
文献类型：期刊论文
| 作者 | Wan, Chunlei; Tai, Jiahui; Zhang, Jie; Guo, Yi; Zhu, Qing; Ling, Ding; Gu, Feng; Gan, Jin; Zhu, Caixia; Wang, Yuyan |
| 刊名 | CELL DEATH & DISEASE
 |
| 出版日期 | 2019-05-21 |
| 卷号 | 10页码:- |
| ISSN号 | 2041-4889 |
| 英文摘要 | Silver nanoparticle (nAg), which is one of the most common manufactured nanomaterials, has a wide range of biomedical applications. The human oncogenic gamma-herpesviruses, Kaposi's sarcoma-associated herpesvirus (KSHV) and Epstein-Barr Virus (EBV), are etiologically linked to many malignancies. Currently, there are no efficient or specific treatments for these types of tumors, and most patients die because of resistance to conventional cytotoxic chemotherapy. Despite nAg having antitumor and antiviral activities, its effects on oncogenic herpesvirus-related cancer cells remain largely unknown. Here, we reveal that nAg presents higher cytotoxicity against KSHV- or EBV-latently infected cells via reactivating viral lytic replication, which relies on the induction of reactive oxygen species (ROS) generation and autophagy. Moreover, nAg blocks KSHV primary infection by directly destroying virion particles, as well as effectively inhibits colony formation and moderately represses the growth of KSHV-associated tumors in xenograft mouse model. Taken together, these results demonstrate the therapeutic potential of nAg for use in the antiviral infection and treatment of oncogenic herpesvirus-related cancers. |
| 源URL | [http://ir.rcees.ac.cn/handle/311016/43012]  |
| 专题 | 生态环境研究中心_环境化学与生态毒理学国家重点实验室 |
| 作者单位 | 1.Chinese Acad Sci, Res Ctr Ecoenvironm Sci, State Key Lab Environm Chem & Ecotoxcicol, Beijing 100085, Peoples R China 2.Fudan Univ, Shanghai Med Coll, Sch Basic Med Sci, MOE & NHC & CAMS Key Lab Med Mol Virol, Shanghai 200032, Peoples R China 3.China Med Univ, Dept Gynecol, Key Lab AIDS Immunol, Minist Hlth,Affiliated Hosp 1, Shenyang 110000, Peoples R China 4.Shanghai Jiao Tong Univ, ShengYushou Ctr Cell Biol & Immunol, Sch Life Sci & Biotechnol, Shanghai 200240, Peoples R China 5.Baoji Cent Hosp, Expert Workstn, Baoji 721008, Peoples R China |
| 推荐引用方式 GB/T 7714 | Wan, Chunlei,Tai, Jiahui,Zhang, Jie,et al. Silver nanoparticles selectively induce human oncogenic gamma-herpesvirus-related cancer cell death through reactivating viral lytic replication[J]. CELL DEATH & DISEASE,2019,10:-. |
| APA | Wan, Chunlei.,Tai, Jiahui.,Zhang, Jie.,Guo, Yi.,Zhu, Qing.,...&Cai, Qiliang.(2019).Silver nanoparticles selectively induce human oncogenic gamma-herpesvirus-related cancer cell death through reactivating viral lytic replication.CELL DEATH & DISEASE,10,-. |
| MLA | Wan, Chunlei,et al."Silver nanoparticles selectively induce human oncogenic gamma-herpesvirus-related cancer cell death through reactivating viral lytic replication".CELL DEATH & DISEASE 10(2019):-. |
入库方式： OAI收割
来源：生态环境研究中心
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