Simple and Efficient Synthesis of Anithiactins A-C, Thiasporine A and Their Potent Antitumor 2,4-Linked Oligothiazole Derivatives
文献类型：期刊论文
| 作者 | Liu, Yi; Ma, Zhanwei; Zhao, Xiangyun; Shan, Qiuli; He, Peng; Du, Yuguo; Wang, Yibin |
| 刊名 | CHEMISTRYSELECT
 |
| 出版日期 | 2019-01-17 |
| 卷号 | 4期号:2页码:742-746 |
| 关键词 | 2,4 '-linked oligothiazole 2-phenylthiazole thiasporine A anithiactins A-C antitumor activity |
| ISSN号 | 2365-6549 |
| 英文摘要 | Directly 2,4-linked oligothiazoles are not only broadly applied in drug discovery but also are the core structural motif of many biological natural products. With this background, we reported a simple and efficient route for the synthesis of four 2-phenylthiazole natural products anithiactins A-C, thiasporine A, and series of their novel 2,4-linked oligothiazole derivatives relies on the one-pot cascade reaction of beta-azido disulfides and commercially carboxyl acids. This approach also represented a remarkably direct and simple route for 2,4-linked oligothiazoles synthesis. By doing so, ten bisthiazoles and terthiazoles were effectively obtained in only 3 similar to 6 linear steps with good to moderate yields. The bioassay results demonstrated that all the phenyl-based oligothiazoles show potent antitumor activities. Among them, terthiazole 28 was the most potent compound with IC50 values of 4.4 mu M, 4.8 mu M against HCT116 and A549 cell lines, respectively. |
| 源URL | [http://ir.rcees.ac.cn/handle/311016/43014]  |
| 专题 | 生态环境研究中心_环境化学与生态毒理学国家重点实验室 |
| 作者单位 | 1.Univ Jinan, Sch Biol Sci & Technol, Jinan 250022, Shandong, Peoples R China 2.State Ocean Adm, Inst Oceanog 1, Key Lab Marine Ecol & Environm Sci & Engn, Qingdao 266061, Peoples R China 3.Yantai Univ, Sch Chem & Chem Engn, Yantai 264005, Peoples R China 4.Chinese Acad Sci, State Key Lab Environm Chem & Ecotoxicol, Res Ctr Ecoenvironm Sci, Beijing 100085, Peoples R China |
| 推荐引用方式 GB/T 7714 | Liu, Yi,Ma, Zhanwei,Zhao, Xiangyun,et al. Simple and Efficient Synthesis of Anithiactins A-C, Thiasporine A and Their Potent Antitumor 2,4-Linked Oligothiazole Derivatives[J]. CHEMISTRYSELECT,2019,4(2):742-746. |
| APA | Liu, Yi.,Ma, Zhanwei.,Zhao, Xiangyun.,Shan, Qiuli.,He, Peng.,...&Wang, Yibin.(2019).Simple and Efficient Synthesis of Anithiactins A-C, Thiasporine A and Their Potent Antitumor 2,4-Linked Oligothiazole Derivatives.CHEMISTRYSELECT,4(2),742-746. |
| MLA | Liu, Yi,et al."Simple and Efficient Synthesis of Anithiactins A-C, Thiasporine A and Their Potent Antitumor 2,4-Linked Oligothiazole Derivatives".CHEMISTRYSELECT 4.2(2019):742-746. |
入库方式： OAI收割
来源：生态环境研究中心
浏览0
下载0
收藏0
其他版本
除非特别说明，本系统中所有内容都受版权保护，并保留所有权利。