Synthesis and biological activities of petrosiols B and D
文献类型：期刊论文
| 作者 | Geng, Jialin; Ren, Qidong; Chang, Caizhu; Xie, Xinni; Liu, Jun; Du, Yuguo |
| 刊名 | RSC ADVANCES
 |
| 出版日期 | 2019-01 |
| 卷号 | 9期号:18页码:10253-10263 |
| ISSN号 | 2046-2069 |
| 英文摘要 | A divergent total synthesis of natural diacetylenic tetraols, petrosiol B and petrosiol D, was accomplished by taking advantage of a carbohydrate chiral template. In particular, petrosiol B, which is the first total synthesis so far, was achieved in 13 linear steps with a 10% overall yield applying Ohira-Bestmann homologation, NaH-mediated dehydrobromination, and Cu(i)-catalyzed Cadiot-Chodkiewicz coupling as the key reaction steps. The synthetic petrosiols B and D were subjected to the study on differentiation activities toward neuronal progenitor PC12 cells. Our results suggested that both petrosiol B and petrosiol D could induce the differentiation of neuronal progenitor PC12 cells via the enhancement of Nrf2 activity. By comparing petrosiols B, D and their natural homologue E, petrosiol B displayed the most intensive cell differentiation activity and the highest Nrf2 activity enhancement as well. |
| 源URL | [http://ir.rcees.ac.cn/handle/311016/43028]  |
| 专题 | 生态环境研究中心_环境化学与生态毒理学国家重点实验室 |
| 作者单位 | 1.Univ Chinese Acad Sci, Sch Chem Sci, Beijing 100049, Peoples R China 2.Chinese Acad Sci, Res Ctr Ecoenvironm Sci, State Key Lab Environm Chem & Ecotoxicol, Beijing 100085, Peoples R China 3.Wuhan Inst Technol, Sch Chem & Environm Engn, Wuhan 430205, Hubei, Peoples R China 4.Jiangxi Normal Univ, Natl Engn Res Ctr Carbohydrate Synth, Nanchang 330022, Jiangxi, Peoples R China |
| 推荐引用方式 GB/T 7714 | Geng, Jialin,Ren, Qidong,Chang, Caizhu,et al. Synthesis and biological activities of petrosiols B and D[J]. RSC ADVANCES,2019,9(18):10253-10263. |
| APA | Geng, Jialin,Ren, Qidong,Chang, Caizhu,Xie, Xinni,Liu, Jun,&Du, Yuguo.(2019).Synthesis and biological activities of petrosiols B and D.RSC ADVANCES,9(18),10253-10263. |
| MLA | Geng, Jialin,et al."Synthesis and biological activities of petrosiols B and D".RSC ADVANCES 9.18(2019):10253-10263. |
入库方式： OAI收割
来源：生态环境研究中心
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