Synthetic phenolic antioxidants and their major metabolites in human fingernail
文献类型：期刊论文
| 作者 | Li, Chao; Cui, Xinyi; Chen, Yi; Liao, Chunyang; Ma, Lena Q. |
| 刊名 | ENVIRONMENTAL RESEARCH
 |
| 出版日期 | 2019-02 |
| 卷号 | 169页码:308-314 |
| ISSN号 | 0013-9351 |
| 关键词 | Synthetic phenolic antioxidants (SPAs) Metabolite Fingernail Noninvasive biomarker Indoor dust Human exposure |
| 英文摘要 | Synthetic phenolic antioxidants (SPAs) have been widely used in foods, polymers, and cosmetics, but very limited information is available about their occurrence in human tissues. In this study, five SPAS, namely 2,6-ditert-butyl-4-methylphenol (BHT), 2-tert-butyl-4-hydroxyanisole (BHA), propyl-, octyl-, and dodecyl-gallate (PG, OG, and DG), and four major metabolites of BHT, including 3,5-di-tert-butyl-4-hydroxybenzaldehyde (BHT-CHO), 2,6-di-tert-butyl-4-(hydroxymethyl) phenol (BHT-OH), 3,5-di-tertbutyl-4-hydroxybenzoic acid (BHT-COOH), and 2,6-di-tert-butyl-1,4-benzoquinone (BHT-Q), were determined in human fingernail samples collected from Nanjing, China. Total concentrations of the nine target analytes (Sigma 9SPAs) were 523-14,000 ng/g. BHT was the predominant SPA compound and detected in all samples at a range of 309-11,400 ng/g. The Sigma 9SPAs was negatively correlated with age of fingernail donors (p < 0.05). In addition, indoor dust samples from the living places of the fingernail providers were collected with aim to better understand the SPA exposure pathways. A positive correlation (p < 0.05) was found only for DG concentrations between paired fingernail and dust samples, while not for other SPAs, suggesting that SPAs accumulated in fingernails may not be mainly from indoor dust. SPAs were measured for the first time in human fingernail, and the elevated concentrations in fingernail suggest that the health risk of SPAs should be paid more attention due to their bioaccumulation potential in human body. Further studies are warranted about exposure pathway, distribution and metabolism of SPAS in human body. |
| 源URL | [http://ir.rcees.ac.cn/handle/311016/43033]  |
| 专题 | 生态环境研究中心_环境化学与生态毒理学国家重点实验室 |
| 作者单位 | 1.Chinese Acad Sci, Res Ctr Ecoenvironm Sci, State Key Lab Environm Chem & Ecotoxicol, Beijing 100085, Peoples R China 2.Nanjing Univ, Sch Environm, State Key Lab Pollut Control & Resource Reuse, Nanjing 210023, Jiangsu, Peoples R China 3.Univ Florida, Soil & Water Sci Dept, Gainesville, FL 32611 USA |
| 推荐引用方式 GB/T 7714 | Li, Chao,Cui, Xinyi,Chen, Yi,et al. Synthetic phenolic antioxidants and their major metabolites in human fingernail[J]. ENVIRONMENTAL RESEARCH,2019,169:308-314. |
| APA | Li, Chao,Cui, Xinyi,Chen, Yi,Liao, Chunyang,&Ma, Lena Q..(2019).Synthetic phenolic antioxidants and their major metabolites in human fingernail.ENVIRONMENTAL RESEARCH,169,308-314. |
| MLA | Li, Chao,et al."Synthetic phenolic antioxidants and their major metabolites in human fingernail".ENVIRONMENTAL RESEARCH 169(2019):308-314. |
入库方式： OAI收割
来源：生态环境研究中心
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