Transcriptomic analysis of Anabas testudineus and its defensive mechanisms in response to persistent organic pollutants exposure
文献类型：期刊论文
| 作者 | Zhang, Wanglong; Xie, Heidi Qunhui; Li, Yunping; Jin, Tao; Li, Jiao; Xu, Li; Zhou, Zhiguang; Zhang, Songyan; Ma, Dan; Hahn, Mark E. |
| 刊名 | SCIENCE OF THE TOTAL ENVIRONMENT
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| 出版日期 | 2019-06-15 |
| 卷号 | 669页码:621-630 |
| ISSN号 | 0048-9697 |
| 关键词 | Pollution adaptation POPs toxicology Comparative transcriptomics Gene family expansion Aryl-hydrocarbon receptor CYP3A |
| 英文摘要 | The freshwater climbing perch (Anabas testudineus) can tolerate water environments contaminated with persistent organic pollutants (POPs). The mechanisms underlying this tolerance are unknown. We used de novo transcriptomic analysis to investigate the defensive mechanisms of A. testudineus against POPs based on its genetic features and biological responses to 2,3,7,8-tetrachlorodibenzo-p-dioxin (TCDD) exposure. Our results revealed a specific expansion of cytochrome P450 (CYP) 3A subfamily, which may be involved in the elimination of certain POPs. In xenobiotic responses, the aryl-hydrocarbon receptor (AhR) pathway represents a critical signaling mechanism, and we characterized four AhR and two AhR nuclear translocator homologs and one AhR repressor (AhRR) gene in A. testudineus. TCDD-induced AhRR and CYP1A mRNA upregulation suggests that negative-feedback regulation of AhR signaling through AhRR helps avoid excessive xenobiotic responses. Furthermore, liver and gill transcriptomic profiles were markedly altered after TCDD exposure, with some of the altered genes being related to common defensive responses reported in other species. Based on the newly identified TCDD-altered genes, several A. testudineus-specific responses are proposed, such as enhanced fatty acid beta-oxidation. The genetic features of CYP3A subfamily and AhR pathway and the TCDD-induced defensive biological processes elucidated here enhance our understanding of A. testudineus defensive responses against POPs. (C) 2019 Elsevier B.V. All rights reserved. |
| 源URL | [http://ir.rcees.ac.cn/handle/311016/43045]  |
| 专题 | 生态环境研究中心_环境化学与生态毒理学国家重点实验室 |
| 作者单位 | 1.Chinese Acad Sci, Res Ctr Ecoenvironm Sci, State Key Lab Environm Chem & Ecotoxicol, Beijing 100085, Peoples R China 2.Univ Chinese Acad Sci, Beijing 100049, Peoples R China 3.BGI Shenzhen, China Natl Genebank Shenzhen, Shenzhen 518083, Peoples R China 4.BGI Qingdao, Qingdao 266510, Peoples R China 5.Natl Res Ctr Environm Anal & Measurement, State Environm Protect Key Lab Dioxin Pollut Cont, Beijing 100029, Peoples R China |
| 推荐引用方式 GB/T 7714 | Zhang, Wanglong,Xie, Heidi Qunhui,Li, Yunping,et al. Transcriptomic analysis of Anabas testudineus and its defensive mechanisms in response to persistent organic pollutants exposure[J]. SCIENCE OF THE TOTAL ENVIRONMENT,2019,669:621-630. |
| APA | Zhang, Wanglong.,Xie, Heidi Qunhui.,Li, Yunping.,Jin, Tao.,Li, Jiao.,...&Zhao, Bin.(2019).Transcriptomic analysis of Anabas testudineus and its defensive mechanisms in response to persistent organic pollutants exposure.SCIENCE OF THE TOTAL ENVIRONMENT,669,621-630. |
| MLA | Zhang, Wanglong,et al."Transcriptomic analysis of Anabas testudineus and its defensive mechanisms in response to persistent organic pollutants exposure".SCIENCE OF THE TOTAL ENVIRONMENT 669(2019):621-630. |
入库方式： OAI收割
来源：生态环境研究中心
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