Chronic thiamethoxam exposure impairs the HPG and HPT axes in adult Chinese rare minnow (Gobiocypris rarus): Docking study, hormone levels, histology, and transcriptional responses
文献类型：期刊论文
| 作者 | Zhu Lifei; Wei, Li; Zha, Jinmiao; Na, Li; Wang, Zijian |
| 刊名 | ECOTOXICOLOGY AND ENVIRONMENTAL SAFETY
 |
| 出版日期 | 2019-12-15 |
| 卷号 | 185页码:- |
| 关键词 | Docking study Plasma hormones Thiamethoxam Chinese rare minnow (Gobiocypris rants) |
| ISSN号 | 0147-6513 |
| 英文摘要 | Thiamethoxam has emerged as an environmental contaminant detected in aqueous environments, and its endocrine-disrupting effect at chronic exposure in teleosts remains unknown. In the present study, a docking experiment and an in vivo test were integrated to systematically explore the toxic mechanisms of thiamethoxam in fish. Histological analysis, plasma VTG and hormone level (E2, 11-KT, T3 and T4) determinations, and HPG and HPT gene expression quantification were performed after Chinese rare minnow (Gobiocypris rants) was exposed to thiamethoxam (0, 0.5, 5, and 50 mu g/L) for 90 days. According to the docking study, thiamethoxam had different interactions with ER alpha, AR and TR alpha via hydrogen bonding. A decrease in body length and plasma T4 was observed in both genders. The histological damage in liver and delayed gonadal development were observed in both genders at 50 mu g/L thiamethoxam treatment. In males, the following HPG axis genes were upregulated: gnrh and cyp19b in the brain; vtg and cyp19a in the liver; and cyp17 and cyp19a in the gonad. In females, era in the liver was significantly upregulated with 0.5 mu g/L thiamethoxam treatment, and cyp17 in the gonad was upregulated with all treatment. The suppression of cyp19a, gnrh, cyp11a, and ttr was observed at the concentration of 5 mu g/L in the female liver. Taken together, the endocrine system of Chinese rare minnow might be disrupted after chronic exposure to thiamethoxam. |
| 源URL | [http://ir.rcees.ac.cn/handle/311016/42630]  |
| 专题 | 生态环境研究中心_环境水质学国家重点实验室 |
| 作者单位 | 1.Chinese Acad Sci, Res Ctr Ecoenvironm Sci, State Key Lab Drinking Water Sci & Technol, Beijing 100085, Peoples R China 2.Chinese Acad Sci, Res Ctr Ecoenvironm Sci, Key Lab Environm Biotechnol, POB 2871, Beijing 100085, Peoples R China 3.Beijing Fisheries Res Inst, Beijing 100068, Peoples R China |
| 推荐引用方式 GB/T 7714 | Zhu Lifei,Wei, Li,Zha, Jinmiao,et al. Chronic thiamethoxam exposure impairs the HPG and HPT axes in adult Chinese rare minnow (Gobiocypris rarus): Docking study, hormone levels, histology, and transcriptional responses[J]. ECOTOXICOLOGY AND ENVIRONMENTAL SAFETY,2019,185:-. |
| APA | Zhu Lifei,Wei, Li,Zha, Jinmiao,Na, Li,&Wang, Zijian.(2019).Chronic thiamethoxam exposure impairs the HPG and HPT axes in adult Chinese rare minnow (Gobiocypris rarus): Docking study, hormone levels, histology, and transcriptional responses.ECOTOXICOLOGY AND ENVIRONMENTAL SAFETY,185,-. |
| MLA | Zhu Lifei,et al."Chronic thiamethoxam exposure impairs the HPG and HPT axes in adult Chinese rare minnow (Gobiocypris rarus): Docking study, hormone levels, histology, and transcriptional responses".ECOTOXICOLOGY AND ENVIRONMENTAL SAFETY 185(2019):-. |
入库方式： OAI收割
来源：生态环境研究中心
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