Injectable Magnetic Liquid-solid Phase Transition Material for MR Imaging and Low-temperature Magnetocaloric Therapy of Osteosarcoma
文献类型：期刊论文
| 作者 | Xu, D; Zhu, YF; Zheng, YY; Luo, Y; Chen, HR |
| 刊名 | JOURNAL OF INORGANIC MATERIALS
 |
| 出版日期 | 2020-11-20 |
| 期号 | 11页码:1277 |
| ISSN号 | 1000-324X |
| DOI | 10.15541/jim20200016 |
| 文献子类 | Article |
| 英文摘要 | Overhigh temperature can induce inflammation and heat radiation damage to normal tissues around the tumor. Therefore, the development of a magnetic material that can achieve high mortality of tumor cells at relatively low temperatures (e.g. 43 degrees C) is critical for the clinical application of magnetocaloric therapy. This study focuses on the goal of low-temperature, safe, and effective magnetic thermotherapy. The liquid-solid phase transition material polylactic acid-glycolic acid (PLGA) approved by the FDA, is selected as raw material and superparamagnetic iron oxide nanoparticles prepared by a one-step mild reduction method are loaded to achieve magnetic resonance imaging and magnetic heating. Meanwhile, a small molecule inhibitor of heat shock protein HSP90, i. e, epigallocatechin gallate (EGCG), encapsulated in PLGA, could inhibit the body's thermal protection function and achieve the purpose of killing tumor cells at lower temperatures. In vitro results indicated that the prepared superparamagnetic iron oxide nanoparticles not only have good T-2-weighted imaging performance, but also show excellent magnetothermal transformation performance. More details, when the obtained PLGA/Fe3O4/EGCG biocomposite was controlled to heated up to 43 degrees C for 40 min under an alternating magnetic field, around 70% of tumor cell could be killed, exhibiting promising potential for low-temperature magnetothermal treatment of tumor. Such novel injectable magnetic thermal phase transition material may provide new idea and material support for the treatment of osteosarcoma. |
| WOS关键词 | IRON-OXIDE NANOPARTICLES |
| WOS研究方向 | Materials Science |
| 语种 | 中文 |
| 出版者 | SCIENCE PRESS |
| 源URL | [http://ir.sic.ac.cn/handle/331005/27617]  |
| 专题 | 中国科学院上海硅酸盐研究所 |
| 推荐引用方式 GB/T 7714 | Xu, D,Zhu, YF,Zheng, YY,et al. Injectable Magnetic Liquid-solid Phase Transition Material for MR Imaging and Low-temperature Magnetocaloric Therapy of Osteosarcoma[J]. JOURNAL OF INORGANIC MATERIALS,2020(11):1277. |
| APA | Xu, D,Zhu, YF,Zheng, YY,Luo, Y,&Chen, HR.(2020).Injectable Magnetic Liquid-solid Phase Transition Material for MR Imaging and Low-temperature Magnetocaloric Therapy of Osteosarcoma.JOURNAL OF INORGANIC MATERIALS(11),1277. |
| MLA | Xu, D,et al."Injectable Magnetic Liquid-solid Phase Transition Material for MR Imaging and Low-temperature Magnetocaloric Therapy of Osteosarcoma".JOURNAL OF INORGANIC MATERIALS .11(2020):1277. |
入库方式： OAI收割
来源：上海硅酸盐研究所
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