Photothermo-Promoted Nanocatalysis Combined with H2S-Mediated Respiration Inhibition for Efficient Cancer Therapy
文献类型：期刊论文
| 作者 | Yang, ZB; Luo, Y; Hu, YA; Liang, KC; He, G; Chen, Q; Wang, QG; Chen, HR |
| 刊名 | ADVANCED FUNCTIONAL MATERIALS
 |
| 出版日期 | 2020-11-07 |
| ISSN号 | 1616-301X |
| DOI | 10.1002/adfm.202007991 |
| 文献子类 | Article; Early Access |
| 英文摘要 | Nanocatalytic medicine has emerged as a promising method for the specific cancer therapy by mediating the interaction between tumor microenvironment biomarkers and nanoagents. However, the produced antitumor cell killing molecules, such as reactive oxygen species (ROS), by catalysis are insufficient to inhibit tumor growth. Herein, a novel kind of polyvinyl pyrrolidone modified multifunctional iron sulfide nanoparticles (Fe1-xS-PVP NPs) is developed via a one-step hydrothermal method, which exhibits high photothermal (PT) conversion efficiency (eta = 24%) under the irradiation of 808 nm near-infrared laser. The increased temperature further facilitates the Fenton reaction to generate abundant center dot OH radicals. More importantly, under an acidic (pH = 6.5) condition within tumor environment, the Fe1-xS-PVP NPs can in situ produce H2S gas, which is evidenced to suppress the activity of enzyme cytochrome c oxidase (COX IV) in cancer cells, contributing to inhibit the growth of tumor. Both in vitro and in vivo results demonstrate that the H2S-mediated gas therapy in combination with PT enhanced ROS achieves excellent antitumor performance, which can open up a new approach for the design of gas-mediated cancer treatment. |
| WOS关键词 | CYTOCHROME-C-OXIDASE ; HYDROGEN-SULFIDE ; TUMOR HYPOXIA ; NANOPARTICLES ; NANOCRYSTALS ; MITOCHONDRIA |
| WOS研究方向 | Chemistry ; Science & Technology - Other Topics ; Materials Science ; Physics |
| 语种 | 英语 |
| 出版者 | WILEY-V C H VERLAG GMBH |
| 源URL | [http://ir.sic.ac.cn/handle/331005/27635]  |
| 专题 | 中国科学院上海硅酸盐研究所 |
| 推荐引用方式 GB/T 7714 | Yang, ZB,Luo, Y,Hu, YA,et al. Photothermo-Promoted Nanocatalysis Combined with H2S-Mediated Respiration Inhibition for Efficient Cancer Therapy[J]. ADVANCED FUNCTIONAL MATERIALS,2020. |
| APA | Yang, ZB.,Luo, Y.,Hu, YA.,Liang, KC.,He, G.,...&Chen, HR.(2020).Photothermo-Promoted Nanocatalysis Combined with H2S-Mediated Respiration Inhibition for Efficient Cancer Therapy.ADVANCED FUNCTIONAL MATERIALS. |
| MLA | Yang, ZB,et al."Photothermo-Promoted Nanocatalysis Combined with H2S-Mediated Respiration Inhibition for Efficient Cancer Therapy".ADVANCED FUNCTIONAL MATERIALS (2020). |
入库方式： OAI收割
来源：上海硅酸盐研究所
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