Tyrosinase-activated prodrug nanomedicine as oxidative stress amplifier for melanoma-specific treatment
文献类型：期刊论文
| 作者 | Pu, YY; Zhou, BG; Xiang, HJ; Wu, WC; Yin, HH; Yue, WW; Yin, YF; Li, HY; Chen, Y; Xu, HX |
| 刊名 | BIOMATERIALS
 |
| 出版日期 | 2020-11-01 |
| ISSN号 | 0142-9612 |
| DOI | 10.1016/j.biomaterials.2020.120329 |
| 文献子类 | Article |
| 英文摘要 | Malignant melanoma is one of the most aggressive skin cancers, posing severe threat to human health. Tyrosinase, overexpressed in melanoma cells, is a specific in-situ weapon to augment the therapeutic efficacy of melanoma-specific treatment by in-situ accelerating the activation of anti-melanoma prodrugs. Herein, we developed a tyrosinase-triggered oxidative stress amplifier, denoted as APAP@PEG/HMnO2, to achieve synergistic chemotherapy and amplified oxidative stress for melanoma-specific treatment. The APAP@PEG/HMnO2 nanosystem was constructed by encapsulating non-toxic prodrug acetaminophen (APAP) into hollow PEG/ HMnO2 nanostructures. After tumor accumulation of APAP@PEG/HMnO2 amplifier, substantial amounts of oxygen (O-2) was generated through reaction between HMnO2 and excessive H2O2 present in tumor environment. Meanwhile, APAP was released at acidic tumor environment and subsequently activated by overexpressed tyrosinase in the presence of O-2 to produce cytotoxic benzoquinone metabolites (AOBQ). On the basis of the combinational effect of AOBQ-triggered reactive oxygen species (ROS) generation and synergistic glutathione (GSH) depletion as promoted by HMnO2 and AOBQ, the APAP@PEG/HMnO2 administration augmented the therapeutic efficacy of chemotherapy by amplifying the intratumoral oxidative stress, thus inducing remarkable cell apoptosis in vitro and tumor suppression in vivo. Therefore, the constructed prodrug nanomedicine represents a prospective tumor-specific therapeutic nanoagent for melanoma treatment. |
| WOS关键词 | TUMOR MICROENVIRONMENT ; NANOPARTICLES ; IPILIMUMAB ; MUTATIONS ; HYPOXIA ; BRAF |
| WOS研究方向 | Engineering ; Materials Science |
| 语种 | 英语 |
| 出版者 | ELSEVIER SCI LTD |
| 源URL | [http://ir.sic.ac.cn/handle/331005/27656]  |
| 专题 | 中国科学院上海硅酸盐研究所 |
| 推荐引用方式 GB/T 7714 | Pu, YY,Zhou, BG,Xiang, HJ,et al. Tyrosinase-activated prodrug nanomedicine as oxidative stress amplifier for melanoma-specific treatment[J]. BIOMATERIALS,2020. |
| APA | Pu, YY.,Zhou, BG.,Xiang, HJ.,Wu, WC.,Yin, HH.,...&Xu, HX.(2020).Tyrosinase-activated prodrug nanomedicine as oxidative stress amplifier for melanoma-specific treatment.BIOMATERIALS. |
| MLA | Pu, YY,et al."Tyrosinase-activated prodrug nanomedicine as oxidative stress amplifier for melanoma-specific treatment".BIOMATERIALS (2020). |
入库方式： OAI收割
来源：上海硅酸盐研究所
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