Highly dispersed nano-enzyme triggered intracellular catalytic reaction toward cancer specific therapy
文献类型：期刊论文
| 作者 | Mei, X; Hu, TT; Wang, H; Liang, RZ; Bu, WB; Wei, M |
| 刊名 | BIOMATERIALS
 |
| 出版日期 | 2020-11-01 |
| ISSN号 | 0142-9612 |
| DOI | 10.1016/j.biomaterials.2020.120257 |
| 文献子类 | Article |
| 英文摘要 | Currently, reactive oxygen species (ROS)-induced apoptosis systems have drawn increasing attention in cancer therapy, owing to their specific tumor inhibition ability and great biocompatibility. Herein, we developed a highly dispersed nano-enzyme based on the assembly of natural glucose oxidase (GOD) onto CoFe-layered double hydroxides (CoFe-LDHs) monolayer nanosheets. By virtue of the high dispersion of Fe3+ within the host layer, the CoFe-LDHs nanosheets exhibit a collaborative enhanced Fenton catalytic activity with a rate constant of 3.26 x 10(-4) s-(1) , which is 1-3 orders of magnitude higher than other iron-containing Fenton reaction agents. Subsequently, with a massive H2O2 triggered by GOD, GOD/CoFe-LDHs nanohybrid converts a cascade of glucose into hydroxyl radicals under tumor acid conditions, which is validated by a high maximum velocity (V-max = 2.23 x 10(-6) M) and low Michaelis-Menten constant (K-M = 5.40 mM). Through the intracellular catalytic Fenton reaction within the tumor environment, both in vitro and in vivo results demonstrate the excellent antitumor effect of GOD/CoFe-LDHs. Therefore, a self-supplied, ultra-efficient and sequential catalytic tumor-specific therapy has been achieved based on GOD/CoFe-LDHs nano-enzyme, which holds great promise in clinical cancer therapy with minimum side effects. |
| WOS关键词 | LAYERED DOUBLE HYDROXIDE ; FENTON REACTION ; TUMOR ; DNA ; NANOPARTICLES ; DELIVERY ; RESONANCE ; WATER ; MRI |
| WOS研究方向 | Engineering ; Materials Science |
| 语种 | 英语 |
| 出版者 | ELSEVIER SCI LTD |
| 源URL | [http://ir.sic.ac.cn/handle/331005/27659]  |
| 专题 | 中国科学院上海硅酸盐研究所 |
| 推荐引用方式 GB/T 7714 | Mei, X,Hu, TT,Wang, H,et al. Highly dispersed nano-enzyme triggered intracellular catalytic reaction toward cancer specific therapy[J]. BIOMATERIALS,2020. |
| APA | Mei, X,Hu, TT,Wang, H,Liang, RZ,Bu, WB,&Wei, M.(2020).Highly dispersed nano-enzyme triggered intracellular catalytic reaction toward cancer specific therapy.BIOMATERIALS. |
| MLA | Mei, X,et al."Highly dispersed nano-enzyme triggered intracellular catalytic reaction toward cancer specific therapy".BIOMATERIALS (2020). |
入库方式： OAI收割
来源：上海硅酸盐研究所
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