A cation exchange strategy to construct a targeting nanoprobe for enhanced T-1-weighted MR imaging of tumors
文献类型：期刊论文
| 作者 | Chen, SY; Zhang, Q; Sun, HT; Zheng, YY; Chen, Q; Luo, Y; Chen, HR; Zhou, Q |
| 刊名 | JOURNAL OF MATERIALS CHEMISTRY B
 |
| 出版日期 | 2020-10-07 |
| 期号 | 37页码:8519 |
| ISSN号 | 2050-750X |
| DOI | 10.1039/d0tb01632b |
| 文献子类 | Article |
| 英文摘要 | Excellent imaging performance and good biocompatibility of contrast agents are considered as prerequisites for accurate tumor diagnosis. In this study, a novel imaging nanoprobe with actively targeting performance based on ultrasmall paramagnetic iron oxide (USPIO) nanoparticles was constructed by a facile cation exchange strategy followed by conjugation with transferrin (Tf). The stable gadolinium (Gd3+) chelation endows the nanoparticles (NPs) with a low value of r(2)/r(1) (1.28) and a relatively high r(1) value of 3.2 mM(-1) s(-1), enabling their use for T-1-weighted positive magnetic resonance (MR) imaging. This constructed transferrin modified gadolinium-iron chelate nanoprobe, named as TUG, shows high biocompatibility within a given dose range. More importantly, compared with clinically used Gd-based small molecule contrast agents, the obtained TUG can be more engulfed by breast cancer cells, showing much enhanced T-1-weighted positive MR imaging in both subcutaneous and orthotopic tumor models of breast cancer. This novel nanoprobe holds great promise to be utilized as a targeting contrast agent with high efficacy for T-1-weighted positive MR imaging. |
| WOS关键词 | IRON-OXIDE NANOPARTICLES ; CONTRAST AGENTS ; RELAXIVITY |
| WOS研究方向 | Materials Science |
| 语种 | 英语 |
| 出版者 | ROYAL SOC CHEMISTRY |
| 源URL | [http://ir.sic.ac.cn/handle/331005/27703]  |
| 专题 | 中国科学院上海硅酸盐研究所 |
| 推荐引用方式 GB/T 7714 | Chen, SY,Zhang, Q,Sun, HT,et al. A cation exchange strategy to construct a targeting nanoprobe for enhanced T-1-weighted MR imaging of tumors[J]. JOURNAL OF MATERIALS CHEMISTRY B,2020(37):8519. |
| APA | Chen, SY.,Zhang, Q.,Sun, HT.,Zheng, YY.,Chen, Q.,...&Zhou, Q.(2020).A cation exchange strategy to construct a targeting nanoprobe for enhanced T-1-weighted MR imaging of tumors.JOURNAL OF MATERIALS CHEMISTRY B(37),8519. |
| MLA | Chen, SY,et al."A cation exchange strategy to construct a targeting nanoprobe for enhanced T-1-weighted MR imaging of tumors".JOURNAL OF MATERIALS CHEMISTRY B .37(2020):8519. |
入库方式： OAI收割
来源：上海硅酸盐研究所
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