Two-dimensional silicene composite nanosheets enable exogenous/endogenous-responsive and synergistic hyperthermia-augmented catalytic tumor theranostics
文献类型：期刊论文
| 作者 | Duan, HC; Guo, HY; Zhang, RF; Wang, FF; Liu, Z; Ge, M; Yu, LD; Lin, H; Chen, Y |
| 刊名 | BIOMATERIALS
 |
| 出版日期 | 2020-10-01 |
| ISSN号 | 0142-9612 |
| DOI | 10.1016/j.biomaterials.2020.120206 |
| 文献子类 | Article |
| 英文摘要 | Silicene as an emerging two-dimensional material (2DM) spurs the broad research interests due to its prominent electronic and physical properties, however, still lacking in exploitation for the biological and medical practices. Herein, we constructed a 2D silicene-based theranostic nanoplatform, MnOx@silicene-BSA (MS-BSA), with tumor microenvironment (TME)-responsive and synergistic hyperthermia-augmented catalytic activity when irradiated by near infrared-II (NIR-II) laser because of the high photothermal-conversion efficiency of 2D silicene matrix. Such MS-BSA nanosheets possess the capability to react with glutathione (GSH) to generate Mn2+ and glutathione disulfide (GSSG) under acidity/reducing TME condition. With the presence/assistance of HCO3-, the released Mn2+ exhibited sensitive catalytic activity towards endogenous H2O2 via Fenton-like reaction, enabling the generation of highly toxic hydroxyl radicals (center dot OH), which finally led to the enhanced nanocatalytic therapeutic efficacy followed by exogenous NIR-II laser exposure, originating from hyperthermia-augmented catalytic activity. Especially, these MS-BSA nanosheets accumulated into the tumor region to enable superb contrast enhancement of TME-responsive T-1-weighted magnetic resonance imaging (MRI) and photoacoustic imaging (PAI), and high-efficient in vivo synergistic tumor eradication. Therefore, such an intelligent photothermal-enhanced catalytic theranostic nanoplatform could realize the exogenous/endogenous-responsive and cooperative hyperthermia-augmented tumor treatment and accurate tumor positioning/monitoring. |
| WOS关键词 | BLACK PHOSPHORUS NANOSHEETS ; PHOTOTHERMAL THERAPY ; IN-VIVO ; GRAPHENE ; GLUTATHIONE ; NANOCARRIERS ; GENERATION ; APOPTOSIS |
| WOS研究方向 | Engineering ; Materials Science |
| 语种 | 英语 |
| 出版者 | ELSEVIER SCI LTD |
| 源URL | [http://ir.sic.ac.cn/handle/331005/27722]  |
| 专题 | 中国科学院上海硅酸盐研究所 |
| 推荐引用方式 GB/T 7714 | Duan, HC,Guo, HY,Zhang, RF,et al. Two-dimensional silicene composite nanosheets enable exogenous/endogenous-responsive and synergistic hyperthermia-augmented catalytic tumor theranostics[J]. BIOMATERIALS,2020. |
| APA | Duan, HC.,Guo, HY.,Zhang, RF.,Wang, FF.,Liu, Z.,...&Chen, Y.(2020).Two-dimensional silicene composite nanosheets enable exogenous/endogenous-responsive and synergistic hyperthermia-augmented catalytic tumor theranostics.BIOMATERIALS. |
| MLA | Duan, HC,et al."Two-dimensional silicene composite nanosheets enable exogenous/endogenous-responsive and synergistic hyperthermia-augmented catalytic tumor theranostics".BIOMATERIALS (2020). |
入库方式： OAI收割
来源：上海硅酸盐研究所
浏览0
下载0
收藏0
其他版本
除非特别说明，本系统中所有内容都受版权保护，并保留所有权利。