Developing New Cancer Nanomedicines by Repurposing Old Drugs
文献类型：期刊论文
| 作者 | Yang, BW; Shi, JL |
| 刊名 | ANGEWANDTE CHEMIE-INTERNATIONAL EDITION
 |
| 出版日期 | 2020-12-01 |
| 期号 | 49页码:21829 |
| ISSN号 | 1433-7851 |
| DOI | 10.1002/anie.202004317 |
| 文献子类 | Review |
| 英文摘要 | The high morbidity and mortality of cancer requires innovative therapeutics. Very recently, several old drugs approved by the U.S. Food and Drug Administration (FDA) or currently undergoing clinical trials, such as 2-deoxy-d-glucose, disulfiram, artemisinin, chloroquine, metformin, and aspirin, which have been extensively applied clinically for the treatment of other diseases with reliable evidence of biosafety, have been engineered into nanosystems for enhancing cancer therapy. These old drugs can cooperate with other components of nanosystems or the ambient biological environment, to favor tumor-specific therapeutics by nontoxicity-to-toxicity transition. This Minireview provides a concentrated summary of the most recent progress made in this emerging field, highlighting the "old drugs, new uses" strategy for the construction of next-generation nanomedicines. It is expected that the clinical translation of nanomedicines can be accelerated by repurposing old drugs to elevate cancer therapeutic efficacy and specificity. |
| WOS关键词 | INTRACELLULAR FATE ; COLORECTAL-CANCER ; PROSTATE-CANCER ; METABOLISM ; 2-DEOXY-D-GLUCOSE ; INHIBITION ; METFORMIN ; TARGETS ; NANOPARTICLES ; CHLOROQUINE |
| WOS研究方向 | Chemistry |
| 语种 | 英语 |
| 出版者 | WILEY-V C H VERLAG GMBH |
| 源URL | [http://ir.sic.ac.cn/handle/331005/27745]  |
| 专题 | 中国科学院上海硅酸盐研究所 |
| 推荐引用方式 GB/T 7714 | Yang, BW,Shi, JL. Developing New Cancer Nanomedicines by Repurposing Old Drugs[J]. ANGEWANDTE CHEMIE-INTERNATIONAL EDITION,2020(49):21829. |
| APA | Yang, BW,&Shi, JL.(2020).Developing New Cancer Nanomedicines by Repurposing Old Drugs.ANGEWANDTE CHEMIE-INTERNATIONAL EDITION(49),21829. |
| MLA | Yang, BW,et al."Developing New Cancer Nanomedicines by Repurposing Old Drugs".ANGEWANDTE CHEMIE-INTERNATIONAL EDITION .49(2020):21829. |
入库方式： OAI收割
来源：上海硅酸盐研究所
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