A tailored positively-charged hydrophobic surface reduces the risk of implant associated infections
文献类型：期刊论文
| 作者 | Shen, J; Gao, P; Han, S; Kao, RYT; Wu, SL; Liu, XY; Qian, S; Chu, PK; Cheung, KMC; Yeung, KWK |
| 刊名 | ACTA BIOMATERIALIA
 |
| 出版日期 | 2020-09-15 |
| 页码 | 421 |
| ISSN号 | 1742-7061 |
| DOI | 10.1016/j.actbio.2020.07.040 |
| 文献子类 | Article |
| 英文摘要 | Implant-associated infections is one of the most challenging post-operative complications in bone-related implantations. To tackle this clinical issue, we developed a low-cost and durable surface coating for medical grade titanium implants that uses positively charged silane molecules. The in vitro antimicrobial tests revealed that the titanium surface coated with (3-aminopropyl) triethoxysilane, which has the appropriate length of hydrophobic alkyl chain and positive charged amino group, suppressed more than 90% of the initial bacterial adhesion of S. aureus, P. aeruginosa, and E. coli after 30 min of incubation. In terms of growth inhibitory rate, the treated surface was able to reduce 75.7% +/- 11.9% of bacterial growth after a 24-hour culturing, thereby exhibiting superior anti-biofilm formation in the late stage. When implanted into the rat model infected by S. aureus, the treated surface eliminated the implant-associated infection through the mechanism of inhibition of bacterial adhesion on the implant surface. Additionally, the treated surface was highly compatible with mammalian cells. In general, our design demonstrated its potential for human clinical trials as a low-cost and effective antibacterial strategy to minimize postoperative implant-related bacterial infection. (C) 2020 Acta Materialia Inc. Published by Elsevier Ltd. All rights reserved. |
| WOS关键词 | IN-VITRO ; BACTERIAL ADHESION ; SILANE COATINGS ; ANTIBACTERIAL ; TITANIUM ; NANOPARTICLES ; BIOMATERIALS ; CYTOTOXICITY ; POLYMER ; DESIGN |
| WOS研究方向 | Engineering ; Materials Science |
| 语种 | 英语 |
| 出版者 | ELSEVIER SCI LTD |
| 源URL | [http://ir.sic.ac.cn/handle/331005/27751]  |
| 专题 | 中国科学院上海硅酸盐研究所 |
| 推荐引用方式 GB/T 7714 | Shen, J,Gao, P,Han, S,et al. A tailored positively-charged hydrophobic surface reduces the risk of implant associated infections[J]. ACTA BIOMATERIALIA,2020:421. |
| APA | Shen, J.,Gao, P.,Han, S.,Kao, RYT.,Wu, SL.,...&Yeung, KWK.(2020).A tailored positively-charged hydrophobic surface reduces the risk of implant associated infections.ACTA BIOMATERIALIA,421. |
| MLA | Shen, J,et al."A tailored positively-charged hydrophobic surface reduces the risk of implant associated infections".ACTA BIOMATERIALIA (2020):421. |
入库方式： OAI收割
来源：上海硅酸盐研究所
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