In situ activated mesenchymal stem cells (MSCs) by bioactive hydrogels for myocardial infarction treatment
文献类型：期刊论文
| 作者 | Gao, L; Yi, M; Xing, M; Li, HK; Zhou, YL; Xu, Q; Zhang, ZWB; Wen, ZP; Chang, J |
| 刊名 | JOURNAL OF MATERIALS CHEMISTRY B
 |
| 出版日期 | 2020-09-14 |
| 期号 | 34页码:7713 |
| ISSN号 | 2050-750X |
| DOI | 10.1039/d0tb01320j |
| 文献子类 | Article |
| 英文摘要 | Stem-cell therapy has been proved as a promising strategy for myocardial infarction (MI) treatment. However, the therapeutic efficacy is mainly limited by the cellular activity of transplanted mesenchymal stem cells (MSCs). In this study, a novel bioglass (BG)/gamma-polyglutamic acid (gamma-PGA)/chitosan (CS) hydrogel was obtained by in situ adding BG to stimulate the imine bond formation. And the effect of the composite hydrogel on MI therapeutic efficacy was evaluated in a rat acute myocardial infarction (AMI) model in vivo and the possible mechanism of the BG/gamma-PGA/CS hydrogel for the stimulation of the intercellular interaction between MSCs and cardiomyocytes (CMs) was explored by a MSC and CM co-culture experiment in vitro. The implantation of the MSC loaded BG/gamma-PGA/CS composite hydrogel in the mice AMI model showed a significant improvement in the therapeutic efficacy with improved cardiac function, attenuation of heart remodeling, reduced cardiomyocyte apoptosis and accelerated vascularization. The in vitro cell experiments demonstrated that the BG/gamma-PGA/CS hydrogel activated the intercellular interaction between MSCs and CMs, which resulted in reduced cell apoptosis and enhanced angiogenesis. Silicate based bioactive hydrogels activated MSCs and cell-cell interactions in cardiac tissue after AMI and significantly enhanced the efficacy, which suggests that this bioactive hydrogel based approach is an effective way to enhance stem-cell therapy. |
| WOS关键词 | ISCHEMIC CARDIOMYOPATHY ; THERAPEUTIC-EFFICACY ; CARDIAC-FUNCTION ; HEART ; TRANSPLANTATION ; REPAIR ; DIFFERENTIATION ; RETENTION ; MODEL |
| WOS研究方向 | Materials Science |
| 语种 | 英语 |
| 出版者 | ROYAL SOC CHEMISTRY |
| 源URL | [http://ir.sic.ac.cn/handle/331005/27760]  |
| 专题 | 中国科学院上海硅酸盐研究所 |
| 推荐引用方式 GB/T 7714 | Gao, L,Yi, M,Xing, M,et al. In situ activated mesenchymal stem cells (MSCs) by bioactive hydrogels for myocardial infarction treatment[J]. JOURNAL OF MATERIALS CHEMISTRY B,2020(34):7713. |
| APA | Gao, L.,Yi, M.,Xing, M.,Li, HK.,Zhou, YL.,...&Chang, J.(2020).In situ activated mesenchymal stem cells (MSCs) by bioactive hydrogels for myocardial infarction treatment.JOURNAL OF MATERIALS CHEMISTRY B(34),7713. |
| MLA | Gao, L,et al."In situ activated mesenchymal stem cells (MSCs) by bioactive hydrogels for myocardial infarction treatment".JOURNAL OF MATERIALS CHEMISTRY B .34(2020):7713. |
入库方式： OAI收割
来源：上海硅酸盐研究所
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