Near-Infrared Light-Triggered Chlorine Radical (Cl-.) Stress for Cancer Therapy
文献类型：期刊论文
| 作者 | Song, RX; Wang, H; Zhang, M; Liu, YY; Meng, XF; Zhai, SJ; Wang, CC; Gong, T; Wu, YL; Jiang, XW |
| 刊名 | ANGEWANDTE CHEMIE-INTERNATIONAL EDITION
 |
| 出版日期 | 2020-11-16 |
| 期号 | 47页码:21032 |
| ISSN号 | 1433-7851 |
| DOI | 10.1002/anie.202007434 |
| 文献子类 | Article |
| 英文摘要 | Free radicals with reactive chemical properties can fight tumors without causing drug resistance. Reactive oxygen species (ROS) has been widely used for cancer treatment, but regrettably, the common O(2)and H(2)O(2)deficiency in tumors sets a severe barrier for sufficient ROS production, leading to unsatisfactory anticancer outcomes. Here, we construct a chlorine radical (Cl-.) nano-generator with SiO2-coated upconversion nanoparticles (UCNPs) on the inside and Ag-0/AgCl hetero-dots on the outside. Upon near-infrared (NIR) light irradiation, the short-wavelength emission UCNP catalyzes(.)Cl generation from Ag-0/AgCl with no dependence on O-2/H2O2.Cl-. with strong oxidizing capacity and nucleophilicity can attack biomolecules in cancer cells more effectively than ROS. This(.)Cl stress treatment will no doubt broaden the family of oxidative stress-induced antitumor strategies by using non-oxygen free radicals, which is significant in the development of new anticancer agents. |
| WOS关键词 | AG-AT-AGCL ; HIGHLY EFFICIENT ; PHOTOCATALYTIC ACTIVITY ; OXIDATIVE STRESS ; STRAND BREAKS ; DEGRADATION ; UV/CHLORINE ; UV ; TRANSFORMATION ; CHEMISTRY |
| WOS研究方向 | Chemistry |
| 语种 | 英语 |
| 出版者 | WILEY-V C H VERLAG GMBH |
| 源URL | [http://ir.sic.ac.cn/handle/331005/27766]  |
| 专题 | 中国科学院上海硅酸盐研究所 |
| 推荐引用方式 GB/T 7714 | Song, RX,Wang, H,Zhang, M,et al. Near-Infrared Light-Triggered Chlorine Radical (Cl-.) Stress for Cancer Therapy[J]. ANGEWANDTE CHEMIE-INTERNATIONAL EDITION,2020(47):21032. |
| APA | Song, RX.,Wang, H.,Zhang, M.,Liu, YY.,Meng, XF.,...&Bu, WB.(2020).Near-Infrared Light-Triggered Chlorine Radical (Cl-.) Stress for Cancer Therapy.ANGEWANDTE CHEMIE-INTERNATIONAL EDITION(47),21032. |
| MLA | Song, RX,et al."Near-Infrared Light-Triggered Chlorine Radical (Cl-.) Stress for Cancer Therapy".ANGEWANDTE CHEMIE-INTERNATIONAL EDITION .47(2020):21032. |
入库方式： OAI收割
来源：上海硅酸盐研究所
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