Osteoblastic and anti-osteoclastic activities of strontium-substituted silicocarnotite ceramics: In vitro and in vivo studies
文献类型：期刊论文
| 作者 | Zeng, JK; Guo, JS; Sun, ZY; Deng, FY; Ning, CQ; Xie, YZ |
| 刊名 | BIOACTIVE MATERIALS
 |
| 出版日期 | 2020-09-01 |
| 期号 | 3页码:435 |
| DOI | 10.1016/j.bioactmat.2020.03.008 |
| 文献子类 | Article |
| 英文摘要 | Osteoporosis bone defect is a refractory orthopaedic disease which characterized by impaired bone quality and bone regeneration capacity. Current therapies, including antiosteoporosis drugs and artificial bone grafts, are not always satisfactory. Herein, a strontium-substituted calcium phosphate silicate bioactive ceramic (Sr-CPS) was fabricated. In the present study, the extracts of Sr-CPS were prepared for in vitro study and Sr-CPS scaffolds were used for in vivo study. The cytocompatibility, osteogenic and osteoclastogenic properties of Sr-CPS extracts were characterized in comparison to CPS. Molecular mechanisms were also evaluated by Western blot. Sr-CPS extracts were found to promote osteogenesis by upregulating Wnt/beta-catenin signal pathways and inhibit osteoclastogenesis through downregulating NF-kappa B signal pathway. In vivo, micro-CT, histological and histomorphometric observation were conducted after 8 weeks of implantation to evaluate the bone formation using calvarial defects model in ovariectomized rats. Compared with CPS, Sr-CPS significantly promoted critical sized ovariectomy (OVX) calvarial defects healing. Among all the samples, Sr-10 showed the best performance due to a perfect match of bone formation and scaffold degradation rates. Overall, the present study demonstrated that Sr-CPS ceramic can dually modulate both bone formation and resorption, which might be a promising candidate for the reconstruction of osteoporotic bone defect. |
| WOS关键词 | BONE ; SILICATE ; DIFFERENTIATION ; OSTEOPOROSIS ; CHEMISTRY ; FRACTURE ; CATENIN |
| WOS研究方向 | Engineering ; Materials Science |
| 语种 | 英语 |
| 出版者 | KEAI PUBLISHING LTD |
| 源URL | [http://ir.sic.ac.cn/handle/331005/27795]  |
| 专题 | 中国科学院上海硅酸盐研究所 |
| 推荐引用方式 GB/T 7714 | Zeng, JK,Guo, JS,Sun, ZY,et al. Osteoblastic and anti-osteoclastic activities of strontium-substituted silicocarnotite ceramics: In vitro and in vivo studies[J]. BIOACTIVE MATERIALS,2020(3):435. |
| APA | Zeng, JK,Guo, JS,Sun, ZY,Deng, FY,Ning, CQ,&Xie, YZ.(2020).Osteoblastic and anti-osteoclastic activities of strontium-substituted silicocarnotite ceramics: In vitro and in vivo studies.BIOACTIVE MATERIALS(3),435. |
| MLA | Zeng, JK,et al."Osteoblastic and anti-osteoclastic activities of strontium-substituted silicocarnotite ceramics: In vitro and in vivo studies".BIOACTIVE MATERIALS .3(2020):435. |
入库方式： OAI收割
来源：上海硅酸盐研究所
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