Bioinspired Copper Single-Atom Catalysts for Tumor Parallel Catalytic Therapy
文献类型：期刊论文
| 作者 | Lu, XY; Gao, SS; Lin, H; Yu, LD; Han, YH; Zhu, PA; Bao, WC; Yao, HL; Chen, Y; Shi, JL |
| 刊名 | ADVANCED MATERIALS
 |
| 出版日期 | 2020-09-01 |
| 期号 | 36 |
| ISSN号 | 0935-9648 |
| DOI | 10.1002/adma.202002246 |
| 文献子类 | Article |
| 英文摘要 | The oxidation of intracellular biomolecules by reactive oxygen species (ROS) forms the basis for ROS-based tumor therapy. However, the current therapeutic modalities cannot catalyze H(2)O(2)and O(2)concurrently for ROS generation, thereby leading to unsatisfactory therapeutic efficacy. Herein, it is reported a bioinspired hollow N-doped carbon sphere doped with a single-atom copper species (Cu-HNCS) that can directly catalyze the decomposition of both oxygen and hydrogen peroxide to ROS, namely superoxide ion (O-2 center dot(-)) and the hydroxyl radical (center dot OH), respectively, in an acidic tumor microenvironment for the oxidation of intracellular biomolecules without external energy input, thus resulting in an enhanced tumor growth inhibitory effect. Notably, the Fenton reaction turnover frequency of Cu species in Cu-HNCS is approximate to 5000 times higher than that of Fe in commercial Fe(3)O(4)nanoparticles. Experimental results and density functional theory calculations reveal that the high catalytic activity of Cu-HNCS originates from the single-atom copper, and the calculation predicts a next-generation Fenton catalyst. This work provides an effective paradigm of tumor parallel catalytic therapy for considerably enhanced therapeutic efficacy. |
| WOS关键词 | OXYGEN REDUCTION ; ACTIVE-SITES ; CANCER ; GENERATION |
| WOS研究方向 | Chemistry ; Science & Technology - Other Topics ; Materials Science ; Physics |
| 语种 | 英语 |
| 出版者 | WILEY-V C H VERLAG GMBH |
| 源URL | [http://ir.sic.ac.cn/handle/331005/27893]  |
| 专题 | 中国科学院上海硅酸盐研究所 |
| 推荐引用方式 GB/T 7714 | Lu, XY,Gao, SS,Lin, H,et al. Bioinspired Copper Single-Atom Catalysts for Tumor Parallel Catalytic Therapy[J]. ADVANCED MATERIALS,2020(36). |
| APA | Lu, XY.,Gao, SS.,Lin, H.,Yu, LD.,Han, YH.,...&Shi, JL.(2020).Bioinspired Copper Single-Atom Catalysts for Tumor Parallel Catalytic Therapy.ADVANCED MATERIALS(36). |
| MLA | Lu, XY,et al."Bioinspired Copper Single-Atom Catalysts for Tumor Parallel Catalytic Therapy".ADVANCED MATERIALS .36(2020). |
入库方式： OAI收割
来源：上海硅酸盐研究所
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