Photothermal Fenton Nanocatalysts for Synergetic Cancer Therapy in the Second Near-Infrared Window
文献类型：期刊论文
| 作者 | Sun, HT; Zhang, YY; Chen, SY; Wang, RZ; Chen, Q; Li, JC; Luo, Y; Wang, XL; Chen, HR |
| 刊名 | ACS APPLIED MATERIALS & INTERFACES
 |
| 出版日期 | 2020-07-08 |
| 期号 | 27页码:30145 |
| ISSN号 | 1944-8244 |
| DOI | 10.1021/acsami.0c07013 |
| 文献子类 | Article |
| 英文摘要 | Chemodynamic therapy (CDT) that utilizes endogenous hydrogen peroxide (H2O2) to produce reactive oxygen species (ROS) to kill cancer cells has shown a promising strategy for malignant tumor treatment. Nevertheless, limited H2O, levels in the tumor microenvironment often compromise the therapeutic benefits of CDT, leading to cancer recurrence and metastasis. Herein, a second near-infrared (NIR-II) photothermal Fenton nanocatalyst (PFN) was developed for activatable magnetic resonance imaging (MRI)-guided synergetic photothermal therapy (PTT) and CDT of pancreatic carcinoma. Such a PFN consists of manganese dioxide (MnO2), copper sulfide (CuS), and human serum albumin (HSA), which serve as the activatable imaging contrast agent, the NIR-II photothermal agent and Fenton catalyst, and the stabilizer, respectively. The acidic tumor microenvironment increased the relaxivity of PFN by 2.1-fold, allowing for improved imaging performance and monitoring of nanoparticle accumulation in tumors. Under NIR-II laser irradiation at 1064 nm, PFN generates local heat, which not only permits PTT but also enhances the nanocatalyst-mediated Fenton-like reaction. As such, PFN exerts a synergetic action to completely ablate xenografted tumor models in living animals, while the sole CDT fails to do so. This study thus provides an NIR-II photothermal nanocatalyst for potential treatment of deep-seated tumors. |
| WOS关键词 | NANOPARTICLES ; NANOPLATFORM |
| WOS研究方向 | Science & Technology - Other Topics ; Materials Science |
| 语种 | 英语 |
| 出版者 | AMER CHEMICAL SOC |
| 源URL | [http://ir.sic.ac.cn/handle/331005/27913]  |
| 专题 | 中国科学院上海硅酸盐研究所 |
| 推荐引用方式 GB/T 7714 | Sun, HT,Zhang, YY,Chen, SY,et al. Photothermal Fenton Nanocatalysts for Synergetic Cancer Therapy in the Second Near-Infrared Window[J]. ACS APPLIED MATERIALS & INTERFACES,2020(27):30145. |
| APA | Sun, HT.,Zhang, YY.,Chen, SY.,Wang, RZ.,Chen, Q.,...&Chen, HR.(2020).Photothermal Fenton Nanocatalysts for Synergetic Cancer Therapy in the Second Near-Infrared Window.ACS APPLIED MATERIALS & INTERFACES(27),30145. |
| MLA | Sun, HT,et al."Photothermal Fenton Nanocatalysts for Synergetic Cancer Therapy in the Second Near-Infrared Window".ACS APPLIED MATERIALS & INTERFACES .27(2020):30145. |
入库方式： OAI收割
来源：上海硅酸盐研究所
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