Piezocatalytic Tumor Therapy by Ultrasound-Triggered and BaTiO3-Mediated Piezoelectricity
文献类型：期刊论文
| 作者 | Zhu, P; Chen, Y; Shi, JL |
| 刊名 | ADVANCED MATERIALS
 |
| 出版日期 | 2020-07-05 |
| 期号 | 29 |
| ISSN号 | 0935-9648 |
| DOI | 10.1002/adma.202001976 |
| 文献子类 | Article |
| 英文摘要 | Ultrasound theranostics features non-invasiveness, minor energy attenuation, and high tissue-penetrating capability, and is playing ever-important roles in the diagnosis and therapy of diseases in clinics. Herein, ultrasound is employed as a microscopic pressure resource to generate reactive oxygen species (ROS) for piezocatalytic tumor therapy under catalytic mediation by piezoelectric tetragonal BaTiO3 (T-BTO). Under the ultrasonic vibration, the electrons and holes are unpaired and they are separated by the piezoelectricity, resulting in the establishment of a strong built-in electric field, which subsequently catalyzes the generation of ROS such as toxic hydroxyl ((OH)-O-center dot) and superoxide radicals (O-center dot(2)-) in situ for tumor eradication. This modality shows intriguing advantages over typical sonoluminescence-activated sonodynamic therapy, such as more stable sensitizers and dynamical control of redox reaction outcomes. Furthermore, according to the finite element modeling simulation, the built-in electric field is capable of modulating the band alignment to make the toxic ROS generation energetically favorable. Both detailed in vitro cellular level evaluation and in vivo tumor xenograft assessment have demonstrated that an injectable T-BTO-nanoparticles-embedded thermosensitive hydrogel will substantially induce ultrasound irradiation-triggered cytotoxicity and piezocatalytic tumor eradication, accompanied by high therapeutic biosafety in vivo. |
| WOS关键词 | BATIO3 ; ENHANCEMENT ; TEMPERATURE ; ENERGY ; ARRAY |
| WOS研究方向 | Chemistry ; Science & Technology - Other Topics ; Materials Science ; Physics |
| 语种 | 英语 |
| 出版者 | WILEY-V C H VERLAG GMBH |
| 源URL | [http://ir.sic.ac.cn/handle/331005/27922]  |
| 专题 | 中国科学院上海硅酸盐研究所 |
| 推荐引用方式 GB/T 7714 | Zhu, P,Chen, Y,Shi, JL. Piezocatalytic Tumor Therapy by Ultrasound-Triggered and BaTiO3-Mediated Piezoelectricity[J]. ADVANCED MATERIALS,2020(29). |
| APA | Zhu, P,Chen, Y,&Shi, JL.(2020).Piezocatalytic Tumor Therapy by Ultrasound-Triggered and BaTiO3-Mediated Piezoelectricity.ADVANCED MATERIALS(29). |
| MLA | Zhu, P,et al."Piezocatalytic Tumor Therapy by Ultrasound-Triggered and BaTiO3-Mediated Piezoelectricity".ADVANCED MATERIALS .29(2020). |
入库方式： OAI收割
来源：上海硅酸盐研究所
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